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Substance Name: ASG 22ME
RN: 1607822-82-1

Note

  • NCI: An antibody drug conjugate (ADC) containing a human monoclonal antibody AGS-22 targeting the cell adhesion molecule nectin-4 and conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), via a proprietary enzyme-cleavable linker (AGS-22CE), with potential antineoplastic activity. The monoclonal antibody moiety of AGS-22CE selectively binds to nectin-4. After internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and induces apoptosis in nectin-4 overexpressing tumor cells. Nectin-4, a tumor associated antigen belonging to the nectin family, is overexpressed in a variety of cancers, including breast, bladder, lung and pancreatic cancer.(NCI Thesaurus)
 
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Names and Synonyms

Name of Substance

  • ASG 22ME

Synonym

  • ASG 22ME6E

Registry Numbers

CAS Registry Number

  • 1607822-82-1

System Generated Number

  • 1607822821