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Substance Name: Cromoglicic acid [INN:BAN]
RN: 16110-51-3
UNII: Y0TK0FS77W
InChIKey: IMZMKUWMOSJXDT-UHFFFAOYSA-N

Note

  • A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.

Molecular Formula

  • C23-H16-O11

Molecular Weight

  • 468.3684
 

Classification Code

  • Drug / Therapeutic Agent

Names and Synonyms

Results Name

  • Cromoglicic acid [INN:BAN]

Name of Substance

  • Cromoglicic acid [INN:BAN]
  • Cromolyn

Synonyms

  • 1,3-Bis(2-carboxychromon-5-yloxy)-2-hydroxypropane
  • 1,3-Di(2-carboxy-4-oxochromen-5-yloxy)propan-2-ol
  • 4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxy-1,3-propanediyl)bis(oxy))bis(4-oxo-
  • 4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxytrimethylene)dioxy)bis(4-oxo-
  • 5,5'-(2-Hydroxytrimethylenedioxy)bis(4-oxochromene-2-carboxylic acid)
  • Acide cromoglicique
  • Acide cromoglicique [INN-French]
  • Acido cromoglicico
  • Acido cromoglicico [INN-Spanish]
  • Acidum cromoglicicum
  • Acidum cromoglicicum [INN-Latin]
  • Cromoglicic acid
  • Cromoglycic acid
  • Cromolyn
  • EINECS 240-279-8
  • HSDB 3308
  • UNII-Y0TK0FS77W

Systematic Names

  • 4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxy-1,3-propanediyl)bis(oxy))bis(4-oxo-
  • 4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxytrimethylene)dioxy)bis(4-oxo- (8CI)
  • Cromoglicic acid

Registry Numbers

CAS Registry Number

  • 16110-51-3

FDA UNII

  • Y0TK0FS77W

Related Registry Number

  • 15826-37-6 (Parent)

System Generated Number

  • 0016110513

Structure Descriptors

InChI

1S/C23H16O11/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30)

InChIKey

IMZMKUWMOSJXDT-UHFFFAOYSA-N

Smiles

c1cc2c(c(c1)OCC(COc3cccc4c3c(=O)cc(o4)C(=O)O)O)c(=O)cc(o2)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 oral > 2150mg/kg (2150mg/kg)   United States Patent Document. Vol. #4407810,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 241 dec deg C   EXP
pKa Dissociation Constant 1.1 (none)   EXP
log P (octanol-water) 1.92 (none)   EXP
Water Solubility 210 mg/L 25 EST
Vapor Pressure 4.11E-20 mm Hg 25 EST
Henry's Law Constant 2.19E-27 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.42E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.