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Substance Name: Talampanel [INN]
RN: 161832-65-1
UNII: CVS43XG1L5
InChIKey: JACAAXNEHGBPOQ-LLVKDONJSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C19-H19-N3-O3

Molecular Weight

  • 337.377
 
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Names and Synonyms

Name of Substance

  • GYKI 53405
  • Talampanel [INN]

Synonyms

  • (R)-(-)-1-(4-Aminophenyl)-3-acetyl-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine
  • (R)-7-Acetyl-5-(p-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo(4,5-h)(2,3)benzodiazepine
  • GYKI 53773
  • LY 300164
  • Talampanel
  • UNII-CVS43XG1L5

Systematic Names

  • 7H-1,3-Dioxolo(4,5-h)(2,3)benzodiazepine, 7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-, (8R)-
  • 7H-1,3-Dioxolo(4,5-h)(2,3)benzodiazepine, 7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-, (R)-
  • 7H-1,3-Dioxolo(4,5-h)(2,3)benzodiazepine, 8,9-dihydro-7-acetyl-5-(4-aminophenyl)-8-methyl-, (R)-

Registry Numbers

CAS Registry Number

  • 161832-65-1

FDA UNII

  • CVS43XG1L5

System Generated Number

  • 0161832651

Structure Descriptors

InChI

1S/C19H19N3O3/c1-11-7-14-8-17-18(25-10-24-17)9-16(14)19(21-22(11)12(2)23)13-3-5-15(20)6-4-13/h3-6,8-9,11H,7,10,20H2,1-2H3/t11-/m1/s1

InChIKey

JACAAXNEHGBPOQ-LLVKDONJSA-N

Smiles

C1(=NN([C@@H](Cc2c1cc1c(c2)OCO1)C)C(=O)C)c1ccc(cc1)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 73500ug/kg (73.5mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
United States Patent Document. Vol. #5519019,
mouse LD50 oral 100mg/kg (100mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
United States Patent Document. Vol. #5519019,