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Substance Name: Grepafloxacin Hydrochloride [USAN]
RN: 161967-81-3
UNII: A4ER1Z8N9N
InChIKey: IEPMBYOIQGCVHO-UHFFFAOYSA-N

Classification Codes

  • Antibacterial
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C19-H22-F-N3-O3.Cl-H

Molecular Weight

  • 395.8597
 
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Names and Synonyms

Name of Substance

  • Grepafloxacin hydrochloride (+-)-
  • Grepafloxacin Hydrochloride [USAN]

Synonyms

  • (+-)-1-Cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid monohydrochloride
  • 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride, (+-)-
  • Grepafloxacin hydrochloride
  • OPC 17116
  • OPC-17116
  • Raxar
  • UNII-A4ER1Z8N9N

Systematic Names

  • 3-Quinolinecarboxylic acid, 1,4-dihydro-1-cyclopropyl-6-fluoro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride, (+-)-
  • 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 161967-81-3

FDA UNII

  • A4ER1Z8N9N

Other Registry Number

  • 173689-78-6

System Generated Number

  • 0161967813

Molecular Formulas

Molecular Formula

  • C19-H22-F-N3-O3.Cl-H

Molecular Formula Fragments

  • C19-H22-F-N3-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C19H22FN3O3.ClH/c1-10-8-22(6-5-21-10)15-7-14-16(11(2)17(15)20)18(24)13(19(25)26)9-23(14)12-3-4-12;/h7,9-10,12,21H,3-6,8H2,1-2H3,(H,25,26);1H

InChIKey

IEPMBYOIQGCVHO-UHFFFAOYSA-N

Smiles

N1[C@@H](C)CN(CC1)c1c(c(c2C([C@@H](CN(c2c1)C1CC1)C(=O)O)=O)C)F.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LD50 intravenous > 100mg/kg (100mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: NAUSEA OR VOMITING
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 464, 1995.
monkey LD50 oral > 2gm/kg (2000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 464, 1995.
mouse LD50 intravenous 69200ug/kg (69.2mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 464, 1995.
mouse LD50 oral 3900mg/kg (3900mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 464, 1995.
mouse LD50 subcutaneous > 2gm/kg (2000mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 464, 1995.
rat LD50 intravenous 152mg/kg (152mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 464, 1995.
rat LD50 oral 3029mg/kg (3029mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 464, 1995.
rat LD50 subcutaneous > 2gm/kg (2000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 464, 1995.
rat LD50 subcutaneous > 2gm/kg (2000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 464, 1995.