Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Clonazepam [USAN:USP:INN:BAN:JAN]
RN: 1622-61-3
UNII: 5PE9FDE8GB
InChIKey: DGBIGWXXNGSACT-UHFFFAOYSA-N

Note

  • An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.

Molecular Formula

  • C15-H10-Cl-N3-O3

Molecular Weight

  • 315.715
 

Classification Codes

Classification Codes

  • Anticonvulsant
  • Anticonvulsants
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • GABA Agents
  • GABA Modulators
  • Human Data
  • Mutation Data
  • Neurotransmitter Agents
  • Reproductive Effect

Superlist Classification Code

  • DEA Schedule IV

Names and Synonyms

Name of Substance

  • Clonazepam
  • Clonazepam [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Clonazepam

Synonyms

  • 1,3-Dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one
  • 2H-1,4-Benzodiazepin-2-one, 5-(2-chlorophenyl)-1,3-dihydro-7-nitro-
  • 2H-1,4-Benzodiazepin-2-one, 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-
  • 5-(2-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one
  • 5-(o-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one
  • 5-(o-Chlorophenyl)-7-nitro-1H-1,4-benzodiazepin-2(3H)-one
  • 5-24-04-00351 (Beilstein Handbook Reference)
  • 7-Nitro-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2(1H)-one
  • Alti-Clonazepam
  • Antelepsin
  • Antilepsin
  • Apetryl
  • BRN 0759557
  • Chlonazepam
  • Cloazepam
  • Clonazepam
  • Clonazepamum
  • Clonazepamum [INN-Latin]
  • Clonex
  • Clonopin
  • EINECS 216-596-2
  • HSDB 3265
  • Iktorivil
  • Kenoket
  • Klonopin
  • Klonopin Rapidly Disintegrating
  • Landsen
  • Lktorivil
  • Lonazep
  • Melzap
  • NSC 179913
  • Paxam
  • Rivotril
  • Ro 4-8180
  • Ro 5-4023
  • Ro 54023
  • Solfidin
  • UNII-5PE9FDE8GB

Systematic Names

  • 2H-1,4-Benzodiazepin-2-one, 5-(2-chlorophenyl)-1,3-dihydro-7-nitro-
  • Clonazepam

Superlist Names

  • Clonazepam
  • DEA No. 2737

Registry Numbers

CAS Registry Number

  • 1622-61-3

FDA UNII

  • 5PE9FDE8GB

Other Registry Number

  • 106955-87-7

System Generated Number

  • 0001622613

Structure Descriptors

InChI

1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20)

InChIKey

DGBIGWXXNGSACT-UHFFFAOYSA-N

Smiles

c1ccc(c(c1)C2=NCC(=O)Nc3c2cc(cc3)[N+](=O)[O-])Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 1329ug/kg/31D (1.329mg/kg) LIVER: LIVER FUNCTION TESTS IMPAIRED American Journal of Gastroenterology. Vol. 83, Pg. 576, 1988.
man TDLo oral 21mg/kg/26W-I (21mg/kg) PERIPHERAL NERVE AND SENSATION: FASCICULATIONS Postgraduate Medical Journal. Vol. 63, Pg. 311, 1987.
mouse LD50 intraperitoneal 13300mg/kg (13300mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 811, 1980.
mouse LD50 intravenous > 18mg/kg (18mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 811, 1980.
mouse LD50 oral 2gm/kg (2000mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 35, Pg. 77, 1983.
mouse LD50 subcutaneous > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. 235, 1982.
rat LD50 intraperitoneal 14200mg/kg (14200mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 811, 1980.
rat LD50 oral > 15gm/kg (15000mg/kg)   Drugs in Japan Vol. 6, Pg. 235, 1982.
rat LD50 subcutaneous > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. 235, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 237.5 deg C   EXP
log P (octanol-water) 2.41 (none)   EXP
Water Solubility 100 mg/L 25 EXP
Vapor Pressure 1.27E-10 mm Hg 25 EST
Henry's Law Constant 7.02E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 4.21E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.