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Substance Name: Roflumilast [USAN:INN]
RN: 162401-32-3
UNII: 0P6C6ZOP5U
InChIKey: MNDBXUUTURYVHR-UHFFFAOYSA-N

Note

  • Inhibits PDE4.

Classification Codes

  • Selective Phosphodiesterase-4 Inhibitor
  • Treatment of Bronchial Asthma and Chronic Obstructive Pulmonary Disease

Molecular Formula

  • C17-H14-Cl2-F2-N2-O3

Molecular Weight

  • 403.2106
 

Names and Synonyms

Name of Substance

  • Roflumilast [USAN:INN]

Synonyms

  • 3-Cyclopropylmethoxy-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
  • B 9302-107
  • B9302-107
  • Benzamide, 3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-
  • BY 217
  • BY217
  • BYK20869
  • Daliresp
  • Daxas
  • Roflumilast
  • UNII-0P6C6ZOP5U

Systematic Names

  • 3-Cyclopropylmethoxy-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
  • Benzamide, 3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-

Registry Numbers

CAS Registry Number

  • 162401-32-3

FDA UNII

  • 0P6C6ZOP5U

System Generated Number

  • 0162401323

Structure Descriptors

InChI

1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)

InChIKey

MNDBXUUTURYVHR-UHFFFAOYSA-N

Smiles

c1cc(c(cc1C(=O)Nc2c(cncc2Cl)Cl)OCC3CC3)OC(F)F