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Substance Name: Ezetimibe [USAN:INN:BAN]
RN: 163222-33-1
UNII: EOR26LQQ24
InChIKey: OLNTVTPDXPETLC-XPWALMASSA-N

Note

  • An azetidine derivative and ANTICHOLESTEREMIC AGENT that inhibits intestinal STEROL absorption. It is used to reduce total CHOLESTEROL; LDL CHOLESTEROL, and APOLIPOPROTEINS B in the treatment of HYPERLIPIDEMIAS.

Molecular Formula

  • C24-H21-F2-N-O3

Molecular Weight

  • 409.4299
 

Classification Codes

  • Anticholesteremic Agents
  • Antihyperlipidemic (Intestinal Cholesterol Absorption Inhibitor)
  • Antimetabolites
  • Hypolipidemic Agents
  • Lipid Regulating Agents

Names and Synonyms

Name of Substance

  • Ezetimibe
  • Ezetimibe [USAN:INN:BAN]

MeSH Heading

  • Ezetimibe

Synonyms

  • (-)-Sch 58235
  • (3R,4S)-1-(p-Fluorophenyl)-3-((3S)-3-(p-fluorophenyl)-3-hydroxypropyl)-4-(p-hydroxyphenyl)-2-azetidinone
  • Ezedoc
  • Ezetimibe
  • Ezetrol
  • HSDB 7737
  • Sch 58235
  • SCH58235
  • UNII-EOR26LQQ24
  • Zetia

Systematic Names

  • 2-Azetidinone, 1-(4-fluorophenyl)-3-((3S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)-, (3R,4S)-
  • 2-Azetidinone, 1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)-, (3R-(3alpha(S*),4beta))-

Mixture Name

  • Vytorin

Registry Numbers

CAS Registry Number

  • 163222-33-1

FDA UNII

  • EOR26LQQ24

System Generated Number

  • 0163222331

Structure Descriptors

InChI

1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1

InChIKey

OLNTVTPDXPETLC-XPWALMASSA-N

Smiles

c1cc(ccc1[C@@H]2[C@H](C(=O)N2c3ccc(cc3)F)CC[C@@H](c4ccc(cc4)F)O)O