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Substance Name: Sintamil
RN: 16398-39-3
UNII: Y7LU3BJ31L
InChIKey: QQYWZPWIDBROOG-UHFFFAOYSA-N

Note

  • Has pronounced sedative properties, but otherwise resembles imipramine.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C18-H19-N3-O4.Cl-H

Molecular Weight

  • 377.826
 
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Names and Synonyms

Name of Substance

  • Sintamil

Synonyms

  • 10-(3-(Dimethylamino)propyl)-2-nitrobenz(b,f)(1,4)oxazepin-11(10H)-one hydrochloride
  • Ciba 2330-Go
  • EINECS 240-449-1
  • Nitroxazepine
  • Sintamil
  • UNII-Y7LU3BJ31L

Systematic Names

  • 10-(3-(Dimethylamino)propyl)-2-nitrodibenz(b,f)(1,4)oxazepin-11(10H)-one monohydrochloride
  • Dibenz(b,f)(1,4)oxazepin-11(10H)-one, 10-(3-(dimethylamino)propyl)-2-nitro-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 16398-39-3

FDA UNII

  • Y7LU3BJ31L

System Generated Number

  • 0016398393

Molecular Formulas

Molecular Formula

  • C18-H19-N3-O4.Cl-H

Molecular Formula Fragments

  • C18-H19-N3-O4
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H19N3O4.ClH/c1-19(2)10-5-11-20-15-6-3-4-7-17(15)25-16-9-8-13(21(23)24)12-14(16)18(20)22;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

InChIKey

QQYWZPWIDBROOG-UHFFFAOYSA-N

Smiles

Cl.CN(C)CCCN1C(=O)c2cc(ccc2Oc3ccccc13)[N+](=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 50mg/kg (50mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Indian Journal of Experimental Biology. Vol. 12, Pg. 252, 1974.
cat LDLo oral 200mg/kg (200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Indian Journal of Experimental Biology. Vol. 12, Pg. 252, 1974.
dog LDLo intramuscular 200mg/kg (200mg/kg)   Indian Journal of Experimental Biology. Vol. 12, Pg. 252, 1974.
dog LDLo intravenous 60mg/kg (60mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Indian Journal of Experimental Biology. Vol. 12, Pg. 252, 1974.
dog LDLo oral 1500mg/kg (1500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE
Indian Journal of Experimental Biology. Vol. 12, Pg. 252, 1974.
monkey LDLo intravenous 40mg/kg (40mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Indian Journal of Experimental Biology. Vol. 12, Pg. 252, 1974.
monkey LDLo oral 1gm/kg (1000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE
Indian Journal of Experimental Biology. Vol. 12, Pg. 252, 1974.
mouse LD50 intramuscular 190mg/kg (190mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Indian Journal of Experimental Biology. Vol. 12, Pg. 252, 1974.
mouse LD50 intraperitoneal 117mg/kg (117mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Indian Journal of Experimental Biology. Vol. 12, Pg. 252, 1974.
mouse LD50 intravenous 51mg/kg (51mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Indian Journal of Experimental Biology. Vol. 12, Pg. 252, 1974.
mouse LD50 oral 629mg/kg (629mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Indian Journal of Experimental Biology. Vol. 12, Pg. 252, 1974.
mouse LD50 subcutaneous 273mg/kg (273mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Indian Journal of Experimental Biology. Vol. 12, Pg. 252, 1974.
rabbit LDLo intravenous 30mg/kg (30mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Indian Journal of Experimental Biology. Vol. 12, Pg. 252, 1974.
rabbit LDLo oral 500mg/kg (500mg/kg) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Indian Journal of Experimental Biology. Vol. 12, Pg. 252, 1974.
rat LD50 intravenous 55mg/kg (55mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Indian Journal of Experimental Biology. Vol. 12, Pg. 252, 1974.
rat LD50 oral 1690mg/kg (1690mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Indian Journal of Experimental Biology. Vol. 12, Pg. 252, 1974.
rat LD50 subcutaneous 1074mg/kg (1074mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Indian Journal of Experimental Biology. Vol. 12, Pg. 252, 1974.