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Substance Name: Dutasteride [USAN:INN:BAN]
RN: 164656-23-9
UNII: O0J6XJN02I
InChIKey: JWJOTENAMICLJG-QWBYCMEYSA-N

Note

  • A 5-ALPHA-REDUCTASE INHIBITOR that is reported to inhibit both type-1 and type2 isoforms of the enzyme and is used to treat BENIGN PROSTATIC HYPERPLASIA.

Molecular Formula

  • C27-H30-F6-N2-O2

Molecular Weight

  • 528.534
 

Classification Codes

  • 5-alpha Reductase Inhibitors
  • Antiviral (COVID-19)
  • Enzyme Inhibitors
  • Hormone Antagonists
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Steroid Synthesis Inhibitors
  • Treatment of Benign Prostatic Hyperplasia (5alpha-Reductase Type 1 and 2 Inhibitor)
  • Urological Agents

Names and Synonyms

Name of Substance

  • Dutasteride
  • Dutasteride [USAN:INN:BAN]

MeSH Heading

  • Dutasteride

Synonyms

  • (5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
  • alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide
  • Avodart
  • Dutasteride
  • GG 745
  • GG-745
  • GI 198745
  • GI198745
  • UNII-O0J6XJN02I

Systematic Name

  • 1H-Indeno(5,4-f)quinoline-7-carboxamide, N-(2,5-bis(trifluoromethyl)phenyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)-

Registry Numbers

CAS Registry Number

  • 164656-23-9

FDA UNII

  • O0J6XJN02I

System Generated Number

  • 0164656239

Structure Descriptors

InChI

InChI=1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1

InChIKey

JWJOTENAMICLJG-QWBYCMEYSA-N

Smiles

C[C@]12CC[C@H]3[C@@H](CC[C@H]4NC(=O)C=C[C@]34C)[C@@H]1CC[C@@H]2C(=O)Nc5cc(ccc5C(F)(F)F)C(F)(F)F