Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Metaxalone [USAN:INN:BAN]
RN: 1665-48-1
UNII: 1NMA9J598Y
InChIKey: IMWZZHHPURKASS-UHFFFAOYSA-N

Note

  • Muscle spasm relaxant.

Molecular Formula

  • C12-H15-N-O3

Molecular Weight

  • 221.2545
 

Classification Codes

  • Drug / Therapeutic Agent
  • Neuromuscular Agents
  • Peripheral Nervous System Agents
  • Relaxant (Skeletal Muscle)

Names and Synonyms

Name of Substance

  • Metaxalone
  • Metaxalone [USAN:INN:BAN]

Synonyms

  • 2-Oxazolidinone, 5-((3,5-dimethylphenoxy)methyl)-
  • 2-Oxazolidinone, 5-((3,5-xylyloxy)methyl)-
  • 5-((3,5-Dimethylphenoxy)methyl)-2-oxazolidinone
  • 5-((3,5-Xylyloxy)methyl)-2-oxazolidinone
  • 5-(3,5-Xyloloxymethyl)oxazolidin-2-one
  • AHR 438
  • AHR-438
  • BRN 0884592
  • CL 39,148
  • EINECS 216-777-6
  • HSDB 3236
  • Metassalone
  • Metassalone [DCIT]
  • Metaxalon
  • Metaxalona
  • Metaxalona [INN-Spanish]
  • Metaxalona [Spanish]
  • Metaxalone
  • Metaxalonum
  • Metaxalonum [INN-Latin]
  • Metaxalonum [Latin]
  • Methaxalonum
  • Methoxolone
  • NSC 170959
  • Skelaxin
  • UNII-1NMA9J598Y
  • Zorane

Systematic Names

  • 2-Oxazolidinone, 5-((3,5-dimethylphenoxy)methyl)-
  • 2-Oxazolidinone, 5-((3,5-xylyloxy)methyl)-
  • 5-((3,5-Dimethylphenoxy)methyl)-2-oxazolidinone
  • Metaxalone

Registry Numbers

CAS Registry Number

  • 1665-48-1

FDA UNII

  • 1NMA9J598Y

Other Registry Number

  • 105801-80-7

System Generated Number

  • 0001665481

Structure Descriptors

InChI

1S/C12H15NO3/c1-8-3-9(2)5-10(4-8)15-7-11-6-13-12(14)16-11/h3-5,11H,6-7H2,1-2H3,(H,13,14)

InChIKey

IMWZZHHPURKASS-UHFFFAOYSA-N

Smiles

Cc1cc(cc(c1)OCC2CNC(=O)O2)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 490mg/kg (490mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 261, 1972.
mouse LD50 oral 1690mg/kg (1690mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: REGIDITY

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 233, Pg. 326, 1978.
rat LD50 intraperitoneal 515mg/kg (515mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 242, 1967.
rat LD50 oral 775mg/kg (775mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 261, 1972.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 122 deg C   EXP
log P (octanol-water) 2.600 (none)   EST
Atmospheric OH Rate Constant 1.71E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.