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Substance Name: Anhydrotetracycline
RN: 1665-56-1
UNII: 7284RM98Q5
InChIKey: CXCVEERYMJZMMM-DOCRCCHOSA-N

Note

  • Impurity in pahrmaceutical preparations of tetracycline.

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data

Molecular Formula

  • C22-H22-N2-O7

Molecular Weight

  • 426.423
 
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Names and Synonyms

Results Name

  • Anhydrotetracycline

Name of Substance

  • 5a,6-Anhydrotetracycline

Synonyms

  • (4S)-Anhydrotetracycline
  • 5a,6-Anhydrotetracycline
  • Anhydrotetracycline
  • UNII-7284RM98Q5

Systematic Name

  • 2-Naphthacenecarboxamide, 1,4,4a,5,12,12a-hexahydro-4-(dimethylamino)-1,12-dioxo-6-methyl-3,10,11,12a-tetrahydroxy-, (4S-(4-alpha,4a-alpha,12a-alpha))-

Registry Numbers

CAS Registry Number

  • 1665-56-1

FDA UNII

  • 7284RM98Q5

System Generated Number

  • 0001665561

Structure Descriptors

InChI

1S/C22H22N2O7/c1-8-9-5-4-6-12(25)13(9)17(26)14-10(8)7-11-16(24(2)3)18(27)15(21(23)30)20(29)22(11,31)19(14)28/h4-6,11,16,25-27,31H,7H2,1-3H3,(H2,23,30)/t11-,16-,22-/m0/s1

InChIKey

CXCVEERYMJZMMM-DOCRCCHOSA-N

Smiles

Oc1cccc2c1c(O)c1C(=O)[C@@]3(C(=O)C(=C(O)[C@H]([C@@H]3Cc1c2C)N(C)C)C(=O)N)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 134mg/kg (134mg/kg)   Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. Vol. 13, Pg. 244, 1966.
mouse LD50 unreported 34mg/kg (34mg/kg)   "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks In New Drugs, Proceedings of the Symposium on Toxicological Testing for Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague, Czechoslovakia, Univerzita Karlova, 1979Vol. -, Pg. 55, 1979.