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Substance Name: Naltrexone hydrochloride [USP]
RN: 16676-29-2
UNII: Z6375YW9SF
InChIKey: RHBRMCOKKKZVRY-ITLPAZOVSA-N
Note
- Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
Molecular Formula
- C20-H23-N-O4.Cl-H
Molecular Weight
- 377.8656
- All
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- Structure Descriptors
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Classification Codes
- Antiviral (COVID-19)
- Mutation Data
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Naltrexone hydrochloride [USP]
Synonyms
- 17-(Cyclopropylmethyl)-4,5-alpha-epoxy-3,14-dihydroxy-morphinan-6-one hydrochloride
- 17-Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
- CCRIS 1168
- CYTO-205
- Depade
- EINECS 240-723-0
- En 1639A
- EN-1639A
- Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-alpha-epoxy-3,14-dihydroxy-, hydrochloride
- Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, hydrochloride, (5-alpha)-
- Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, hydrochloride, (5alpha)-
- N-Cyclopropylmethyl-noroxymorphone hydrochloride
- Naltrexone HCl
- Naltrexone hydrochloride
- NIH 8503
- ReVia
- Trexan
- UNII-Z6375YW9SF
Systematic Names
- (5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
- Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-alpha-oxy-3,14-dihydoxy-, hydrochloride
- Naltrexone hydrochloride
Mixture Name
- Embeda
Registry Numbers
CAS Registry Number
- 16676-29-2
FDA UNII
- Z6375YW9SF
System Generated Number
- 0016676292
Molecular Formulas
Molecular Formula
- C20-H23-N-O4.Cl-H
Molecular Formula Fragments
- C20-H23-N-O4
- Cl-H
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1InChIKey
RHBRMCOKKKZVRY-ITLPAZOVSA-NSmiles
Cl.Oc1ccc2C[C@H]3N(CC4CC4)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | oral | 1490mg/kg (1490mg/kg) | Medicamentos de Actualidad. Vol. 21, Pg. 264, 1985. | |
monkey | LD50 | oral | 3gm/kg (3000mg/kg) | Medicamentos de Actualidad. Vol. 21, Pg. 264, 1985. | |
mouse | LD50 | oral | 1100mg/kg (1100mg/kg) | Medicamentos de Actualidad. Vol. 21, Pg. 264, 1985. | |
rat | LD50 | oral | 1450mg/kg (1450mg/kg) | Medicamentos de Actualidad. Vol. 21, Pg. 264, 1985. |