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Substance Name: Ornidazole [USAN:INN]
RN: 16773-42-5
UNII: 62XCK0G93T
InChIKey: IPWKIXLWTCNBKN-UHFFFAOYSA-N

Note

  • A nitroimidazole antiprotozoal agent used in ameba and trichomonas infections. It is partially plasma-bound and also has radiation-sensitizing action.

Molecular Formula

  • C7-H10-Cl-N3-O3

Molecular Weight

  • 219.627
 

Classification Codes

  • Amebicides
  • Anti-Infective
  • Anti-Infective Agents
  • Antiparasitic Agents
  • Antiprotozoal Agents
  • Antitrichomonal Agents
  • Drug / Therapeutic Agent
  • Mutation Data
  • Radiation-Sensitizing Agents
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Ornidazole
  • Ornidazole [USAN:INN]

MeSH Heading

  • Ornidazole

Synonyms

  • 1-(2-Hydroxy-3-chloropropyl)-2-methyl-5-nitroimidazole
  • 1-(3-Chloro-2-hydroxypropyl)-2-methyl-5-nitroimidazole
  • 5-23-05-00072 (Beilstein Handbook Reference)
  • alpha-(Chlormethyl)-2-methyl-5-nitro-imidazol-1-aethanol
  • alpha-(Chlormethyl)-2-methyl-5-nitro-imidazol-1-aethanol [German]
  • alpha-(Chloromethyl)-2-methyl-5-nitroimidazole-1-ethanol
  • BRN 0614299
  • CCRIS 9030
  • EINECS 240-826-0
  • Madelen
  • NSC 95075
  • Ornidazol
  • Ornidazol [INN-Spanish]
  • Ornidazole
  • Ornidazolum
  • Ornidazolum [INN-Latin]
  • Ro 7-0207
  • Tiberal
  • UNII-62XCK0G93T

Systematic Names

  • 1H-Imidazole-1-ethanol, alpha-(chloromethyl)-2-methyl-5-nitro-
  • alpha-(Chloromethyl)-2-methyl-5-nitro-1H-imidazole-1-ethanol (9CI)
  • Imidazole-1-ethanol, alpha-(chloromethyl)-2-methyl-5-nitro-
  • Ornidazole

Registry Numbers

CAS Registry Number

  • 16773-42-5

FDA UNII

  • 62XCK0G93T

System Generated Number

  • 0016773425

Structure Descriptors

InChI

1S/C7H10ClN3O3/c1-5-9-3-7(11(13)14)10(5)4-6(12)2-8/h3,6,12H,2,4H2,1H3

InChIKey

IPWKIXLWTCNBKN-UHFFFAOYSA-N

Smiles

Cc1ncc(n1CC(CCl)O)[N+](=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1120mg/kg (1120mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 612, 1978.
mouse LD50 intravenous 375mg/kg (375mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 612, 1978.
mouse LD50 oral 1139mg/kg (1139mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 612, 1978.
rabbit LD50 oral > 2gm/kg (2000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 612, 1978.
rat LD50 oral 1780mg/kg (1780mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 612, 1978.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 77-78 deg C   EXP
log P (octanol-water) 0.6 (none)   EXP
Water Solubility 4330 mg/L 25 EST
Vapor Pressure 2.17E-08 mm Hg 25 EST
Henry's Law Constant 7.92E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 8.72E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.