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Substance Name: Drofenine [INN]
RN: 1679-76-1
UNII: 4QWV355536
InChIKey: AGJBLWCLQCKRJP-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C20-H31-N-O2

Molecular Weight

  • 317.47
 
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Names and Synonyms

Name of Substance

  • Cycloadiphenine
  • Drofenine
  • Drofenine [INN]

Synonyms

  • 2-(Diethylamino)ethyl cyclohexylphenylacetate
  • 4-09-00-02145 (Beilstein Handbook Reference)
  • Adiphenine H
  • alpha-Cyclohexylbenzeneacetic acid 2-(diethylamino)ethyl ester
  • alpha-Phenylcyclohexaneacetic acid 2-(diethylamino)ethyl ester
  • BRN 2059173
  • Cycloadiphene
  • Drofenina
  • Drofenina [INN-Spanish]
  • Drofenine
  • Drofenine [INN-French]
  • Drofeninum
  • Drofeninum [INN-Latin]
  • Hexahydroadiphenine
  • Trasentine 6H
  • Trasentine-6H
  • UNII-4QWV355536

Systematic Names

  • 2-(Diethylamino)ethyl alpha-phenylcyclohexaneacetate
  • alpha-Phenyl-2-(diethylamino)ethylcyclohexaneacetic acid
  • Benzeneacetic acid, alpha-cyclohexyl-, 2-(diethylamino)ethyl ester (9CI)
  • Cyclohexaneacetic acid, alpha-phenyl-, 2-(diethylamino)ethyl ester

Registry Numbers

CAS Registry Number

  • 1679-76-1

FDA UNII

  • 4QWV355536

Related Registry Number

  • 548-66-3 (hydrochloride)

System Generated Number

  • 0001679761

Structure Descriptors

InChI

1S/C20H31NO2/c1-3-21(4-2)15-16-23-20(22)19(17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5,7-8,11-12,18-19H,3-4,6,9-10,13-16H2,1-2H3

InChIKey

AGJBLWCLQCKRJP-UHFFFAOYSA-N

Smiles

C1CCCC(C1)[C@@H](C(OCCN(CC)CC)=O)c1ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 subcutaneous 500mg/kg (500mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE WEAKNESS
British Journal of Pharmacology and Chemotherapy. Vol. 14, Pg. 559, 1959.
rabbit LD subcutaneous > 200mg/kg (200mg/kg)   Acta Physiologica et Pharmacologica Neerlandica. Vol. 1, Pg. 4, 1950.
rabbit LDLo intravenous 40mg/kg (40mg/kg)   Acta Physiologica et Pharmacologica Neerlandica. Vol. 1, Pg. 4, 1950.
rat LD50 intravenous 37mg/kg (37mg/kg)   American Journal of Digestive Diseases. Vol. 18, Pg. 241, 1951.
rat LDLo oral 1600mg/kg (1600mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Acta Physiologica et Pharmacologica Neerlandica. Vol. 1, Pg. 4, 1950.
rat LDLo subcutaneous 1600mg/kg (1600mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Acta Physiologica et Pharmacologica Neerlandica. Vol. 1, Pg. 4, 1950.