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Substance Name: Cosyntropin [USAN]
RN: 16960-16-0
UNII: 72YY86EA29
InChIKey: ZOEFCCMDUURGSE-CQVUSSRSSA-N

Note

  • A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of ADRENOCORTICOTROPIC HORMONE. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of CORTICOSTEROIDS in the ADRENAL CORTEX.

Molecular Formula

  • C136-H210-N40-O31-S

Molecular Weight

  • 2933.47
 

Classification Codes

  • Drug / Therapeutic Agent
  • Hormone (Adrenocorticotropic)
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Human Data

Names and Synonyms

Name of Substance

  • Cosyntropin
  • Cosyntropin [USAN]
  • Tetracosactide [INN]

MeSH Heading

  • Cosyntropin

Synonyms

  • (1-24)alpha-ACTH
  • Acth 1-24
  • Acth(sup 1-24)
  • Acth-Z
  • Acthalpha(1-24)
  • ACTHalpha1-24
  • Actholain
  • Adrenocorticotropic hormone 1-24
  • alpha 1-24 Corticotropin
  • alpha(sup 1-24)-Acth
  • Ba 30920
  • Ba 36716
  • beta(1-24)-Tetracosactide
  • beta(sup 1-24)-Corticotropin
  • beta(sup 1-24)-Tetracosactide
  • beta-1,24-Corticotrophin
  • beta-Corticotrophin-(1-24)-tetracosapeptide
  • BRN 0940671
  • Corticotropin-(1-24)
  • Cortrophin S
  • Cortrosinta
  • Cortrosyn
  • Cosyntropin
  • EINECS 241-031-1
  • HSDB 3307
  • L-Seryl-L-tyrosyl-L-seryl-L-methionyl-L-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-proline
  • Nuvacthen depot
  • Porcine ACTH (1-24)
  • Synacthen
  • Synacthen Depot
  • Synacthene-retard
  • Tetracosactid
  • Tetracosactida
  • Tetracosactida [INN-Spanish]
  • Tetracosactide
  • Tetracosactidum
  • Tetracosactidum [INN-Latin]
  • Tetracosactrin
  • Tetracosapeptide
  • UNII-72YY86EA29

Systematic Names

  • alpha(sup 1-24)-Corticotropin
  • alpha1-24-Corticotropin
  • Tetracosactide

Registry Numbers

CAS Registry Number

  • 16960-16-0

FDA UNII

  • 72YY86EA29

Other Registry Numbers

  • 17008-05-8
  • 35-33-6
  • 37341-02-9
  • 52051-40-8

System Generated Number

  • 0016960160

Structure Descriptors

InChI

1S/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(H,166,196)(H,167,190)(H,168,191)(H,169,202)(H,170,195)(H,171,193)(H,172,198)(H,173,199)(H,183,184)(H,206,207)(H4,142,143,149)(H4,144,145,150)(H4,146,147,151)/t86?,88-,89-,90+,91-,92+,93+,94+,95+,96-,97+,98+,99+,100+,101+,102+,103+,104+,105+,109+,110+,111+/m1/s1

InChIKey

ZOEFCCMDUURGSE-CQVUSSRSSA-N

Smiles

C1CN([C@@H](C1)C(=O)O)C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1C([C@H](NC([C@H](NC([C@H](NC([C@H](NC(CNC([C@@H](NC([C@H]1N(C([C@@H](NC(CNC(=O)[C@H](Cc2c[nH]c3c2cccc3)NC([C@@H](NC([C@@H](NC([C@H](Cc2cnc[nH]2)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@@H](NC([C@@H](CO)N)=O)Cc2ccc(cc2)O)=O)Cc2ccccc2)=O)CCCNC(N)=N)=O)=O)CCCCN)=O)CCC1)=O)C(C)C)=O)=O)CCCCN)=O)CCCCN)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)C(C)C)=O)CCCCN)=O)C(C)C)=O)Cc1ccc(cc1)O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
women LDLo intramuscular 5ug/kg (0.005mg/kg) CARDIAC: CHANGE IN RATE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 JAMA, Journal of the American Medical Association. Vol. 237, Pg. 879, 1977.