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Substance Name: Cosyntropin [USAN]
RN: 16960-16-0
UNII: 72YY86EA29
InChIKey: ZOEFCCMDUURGSE-CQVUSSRSSA-N
Note
- A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of ADRENOCORTICOTROPIC HORMONE. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of CORTICOSTEROIDS in the ADRENAL CORTEX.
Molecular Formula
- C136-H210-N40-O31-S
Molecular Weight
- 2933.47
Classification Codes
- Drug / Therapeutic Agent
- Hormone (Adrenocorticotropic)
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Human Data
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Names and Synonyms
Name of Substance
- Cosyntropin
- Cosyntropin [USAN]
- Tetracosactide [INN]
MeSH Heading
- Cosyntropin
Synonyms
- (1-24)alpha-ACTH
- Acth 1-24
- Acth(sup 1-24)
- Acth-Z
- Acthalpha(1-24)
- ACTHalpha1-24
- Actholain
- Adrenocorticotropic hormone 1-24
- alpha 1-24 Corticotropin
- alpha(sup 1-24)-Acth
- Ba 30920
- Ba 36716
- beta(1-24)-Tetracosactide
- beta(sup 1-24)-Corticotropin
- beta(sup 1-24)-Tetracosactide
- beta-1,24-Corticotrophin
- beta-Corticotrophin-(1-24)-tetracosapeptide
- BRN 0940671
- Corticotropin-(1-24)
- Cortrophin S
- Cortrosinta
- Cortrosyn
- Cosyntropin
- EINECS 241-031-1
- HSDB 3307
- L-Seryl-L-tyrosyl-L-seryl-L-methionyl-L-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-proline
- Nuvacthen depot
- Porcine ACTH (1-24)
- Synacthen
- Synacthen Depot
- Synacthene-retard
- Tetracosactid
- Tetracosactida
- Tetracosactida [INN-Spanish]
- Tetracosactide
- Tetracosactidum
- Tetracosactidum [INN-Latin]
- Tetracosactrin
- Tetracosapeptide
- UNII-72YY86EA29
Systematic Names
- alpha(sup 1-24)-Corticotropin
- alpha1-24-Corticotropin
- Tetracosactide
Registry Numbers
CAS Registry Number
- 16960-16-0
FDA UNII
- 72YY86EA29
Other Registry Numbers
- 17008-05-8
- 35-33-6
- 37341-02-9
- 52051-40-8
System Generated Number
- 0016960160
Structure Descriptors
InChI
InChI=1S/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(H,166,196)(H,167,190)(H,168,191)(H,169,202)(H,170,195)(H,171,193)(H,172,198)(H,173,199)(H,183,184)(H,206,207)(H4,142,143,149)(H4,144,145,150)(H4,146,147,151)/t86?,88-,89-,90+,91-,92+,93+,94+,95+,96-,97+,98+,99+,100+,101+,102+,103+,104+,105+,109+,110+,111+/m1/s1InChIKey
ZOEFCCMDUURGSE-CQVUSSRSSA-NSmiles
CSCC[C@H](NC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
women | LDLo | intramuscular | 5ug/kg (0.005mg/kg) | CARDIAC: CHANGE IN RATE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: CYANOSIS | JAMA, Journal of the American Medical Association. Vol. 237, Pg. 879, 1977. |