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Substance Name: Ruboxistaurin [INN]
RN: 169939-94-0
UNII: 721809WQCP
InChIKey: ZCBUQCWBWNUWSU-SFHVURJKSA-N

Note

  • Inhibits protein kinase C beta.

Molecular Formula

  • C28-H28-N4-O3

Molecular Weight

  • 468.5542
 

Classification Codes

  • Enzyme Inhibitors
  • Protein Kinase C Inhibitor
  • Treatment of Diabetic Retinopathy
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Names and Synonyms

Name of Substance

  • Ruboxistaurin
  • Ruboxistaurin [INN]

Synonyms

  • (9S)-9-((Dimethylamino)methyl)-6,7,10,11-tetrahydro-9H,19H-5,21:12,17-dimethenodibenzo(e,k)pyrrolo(3,4-h)(1,4,13)oxadiazacyclohexadecene-18,20-dione
  • 13-((Dimethylamino)methyl)-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo(e,k)pyrrolo(3,4-h)(1,4,13)oxadiazacyclohexadecene-1,3(2H)-dione
  • LY 333531
  • LY-333531
  • Ruboxistaurin
  • UNII-721809WQCP

Systematic Name

  • 9H,18H-5,21:12,17-Dimethenodibenzo(e,k)pyrrolo(3,4-h)(1,4,13)oxadiazacyclohexadecine-18,20(19H)-dione, 9-((dimethylamino)methyl)-6,7,10,11-tetrahydro-, (9S)-

Registry Numbers

CAS Registry Number

  • 169939-94-0

FDA UNII

  • 721809WQCP

System Generated Number

  • 0169939940

Structure Descriptors

InChI

InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1

InChIKey

ZCBUQCWBWNUWSU-SFHVURJKSA-N

Smiles

CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c4cn(CCO1)c5ccccc45)c6ccccc26