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Substance Name: FTI 277
RN: 170006-73-2
InChIKey: GKFPROVOIQKYTO-UZLBHIALSA-N

Note

  • A ras CAAX (C - Cys; A - aliphatic amino acid; X - Ser or Met) peptidomimetic; inhibits farnesyltransferase; blocks Ras oncogenic signaling by accumulating Ras/Raf complexes in the cytoplasm.

Classification Codes

  • Enzyme Inhibitors
  • Radiation-Sensitizing Agents

Molecular Formula

  • C22-H29-N3-O3-S2

Molecular Weight

  • 447.6211
 
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Names and Synonyms

Name of Substance

  • FTI 277

Synonyms

  • FTI-277
  • L-Methionine, N-((5-((2-amino-3-mercaptopropyl)amino)(1,1'-biphenyl)-2-yl)carbonyl)-, methyl ester, (R)-

Registry Numbers

CAS Registry Number

  • 170006-73-2

Other Registry Number

  • 171744-10-8

System Generated Number

  • 0170006732

Structure Descriptors

InChI

1S/C22H29N3O3S2/c1-28-22(27)20(10-11-30-2)25-21(26)18-9-8-17(24-13-16(23)14-29)12-19(18)15-6-4-3-5-7-15/h3-9,12,16,20,24,29H,10-11,13-14,23H2,1-2H3,(H,25,26)/t16-,20+/m1/s1

InChIKey

GKFPROVOIQKYTO-UZLBHIALSA-N

Smiles

COC(=O)[C@H](CCSC)NC(=O)c1ccc(NC[C@@H](N)CS)cc1c2ccccc2