Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Enzastaurin [INN]
RN: 170364-57-5
UNII: UC96G28EQF
InChIKey: AXRCEOKUDYDWLF-UHFFFAOYSA-N

Notes

  • A protein kinase Cbeta-selective inhibitor.

    NCI: The hydrochloride salt of enzastaurin, a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP-binding site, enzastaurin selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden. ... (NCI Thesaurus)
  • Protein kinase Cbeta-selective inhibitor.

Molecular Formula

  • C32-H29-N5-O2

Molecular Weight

  • 515.6141
 
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Enzastaurin
  • Enzastaurin [INN]

Synonyms

  • Enzastaurin
  • LY317615
  • UNII-UC96G28EQF

Systematic Name

  • 1H-Pyrrole-2,5-dione, 3-(1-methyl-1H-indol-3-yl)-4-(1-(1-(2-pyridinylmethyl)-4-piperidinyl)-1H-indol-3-yl)-

Registry Numbers

CAS Registry Number

  • 170364-57-5

FDA UNII

  • UC96G28EQF

System Generated Number

  • 0170364575

Structure Descriptors

InChI

1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39)

InChIKey

AXRCEOKUDYDWLF-UHFFFAOYSA-N

Smiles

Cn1cc(c2c1cccc2)C3=C(C(=O)NC3=O)c4cn(c5c4cccc5)C6CCN(CC6)Cc7ccccn7