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Substance Name: Propoxyphene napsylate
RN: 17140-78-2
UNII: 5O7IW35N3C
InChIKey: VZPXFHVJUUSVLH-MYXGOWFTSA-N

Note

  • Less potent, but less irritating analog of propoxyphene; used as analgesic; the dextro isomer has little antitussive action but the levo is mainly used as an antitussive effects toxicity as.

Molecular Formulas

  • C10-H8-O3-S.C22-H29-N-O2
  • C22-H29-N-O2.C10-H8-O3-S

Molecular Weight

  • 547.7123
 

Classification Codes

  • Human Data
  • Reproductive Effect
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Names and Synonyms

Results Name

  • Propoxyphene napsylate

Name of Substance

  • Propoxyphene napsylate
  • Propoxyphene napsylate anhydrous

Synonyms

  • (+)- Propoxyphene napsylate
  • 2-Butanol, 4-(dimethylamino)-3-methyl-1,2-diphenyl-, propionate, 2-naphthalenesulfonate
  • Darvon N
  • Darvon-N
  • Dextropropoxyphene Napsylate
  • EINECS 241-205-7
  • Propoxyphene 2-naphthalenesulfonate
  • Propoxyphene napsylate
  • Propoxyphene-N
  • UNII-5O7IW35N3C

Systematic Names

  • 2-Naphthalenesulfonic acid, compd. with (+)-alpha-(2-dimethylamino)-1-methylethyl-alpha-phenylphenethyl propionate (1:1)
  • 2-Naphthalenesulfonic acid, compd. with (S-(R*,S*))-3-(dimethylamino)-2-methyl-1-phenyl-1-(phenylmethyl)p- ropyl propanoate (1:1)
  • Benzeneethanol, alpha-(2-(dimethylamino)-1-methylethyl)-alpha-phenyl-, propanoate (ester), (1S,2R)-, 2-naphthalenesulfonate (salt)
  • Benzeneethanol, alpha-(2-(dimethylamino)-1-methylethyl)-alpha-phenyl-, propanoate (ester), (S-(R*,S*))-, 2-naphthalenesulfonate (salt)
  • Naphthalene-2-sulphonic acid, compound with (S-(R*,S*))-1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl propionate (1:1)

Registry Numbers

CAS Registry Number

  • 17140-78-2

FDA UNII

  • 5O7IW35N3C

Other Registry Number

  • 23239-43-2

System Generated Number

  • 0017140782

Molecular Formulas

Molecular Formulas

  • C10-H8-O3-S.C22-H29-N-O2
  • C22-H29-N-O2.C10-H8-O3-S

Molecular Formula Fragments

  • C10-H8-O3-S
  • C22-H29-N-O2
  • COMPONENT

Structure Descriptors

InChI

1S/C22H29NO2.C10H8O3S/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19;11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10/h6-15,18H,5,16-17H2,1-4H3;1-7H,(H,11,12,13)/t18-,22+;/m1./s1

InChIKey

VZPXFHVJUUSVLH-MYXGOWFTSA-N

Smiles

CCC(=O)O[C@@](Cc1ccccc1)([C@H](C)CN(C)C)c2ccccc2.OS(=O)(=O)c3ccc4ccccc4c3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 129mg/kg (129mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

VASCULAR: OTHER CHANGES
Journal of Toxicology, Clinical Toxicology. Vol. 23, Pg. 347, 1985.
mouse LD50 oral 915mg/kg (915mg/kg)   Toxicology and Applied Pharmacology. Vol. 19, Pg. 445, 1971.
rabbit LDLo oral 183mg/kg (183mg/kg)   Toxicology and Applied Pharmacology. Vol. 19, Pg. 445, 1971.
rat LD50 oral 647mg/kg (647mg/kg)   Toxicology and Applied Pharmacology. Vol. 19, Pg. 445, 1971.