Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: N-(2-hydroxypropyl)methacrylamide co-polymer-doxorubicin conjugate
RN: 171714-74-2

Note

  • PK1 (FCE-28068) is an N-(2-hydroxypropyl) methacrylamide (HPMA) co-polymer-doxorubicin conjugate, attached by a peptide linker; in phase II trials for breast, non-small-cell lung and colon cancers (6/2003).
 

Classification Code

  • Drug / Therapeutic Agent
* denotes mobile formatted website

Links to Resources

NLM Resources (File Locators)

Other Resources (Internet Locators)

Names and Synonyms

Name of Substance

  • N-(2-hydroxypropyl)methacrylamide co-polymer-doxorubicin conjugate

Synonyms

  • FCE 28068
  • FCE-28068
  • FCE28068
  • HPMA-co-polymer-doxorubicin conjugate
  • N-(2-Hydroxypropyl)methacrylamide copolymer - doxorubicin
  • PK1
  • PK1 compound

Systematic Name

  • FCE 28068

Registry Numbers

CAS Registry Number

  • 171714-74-2

System Generated Number

  • 0171714742

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 63mg/kg (63mg/kg) BLOOD: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Human & Experimental Toxicology. Vol. 17, Pg. 93, 1998.