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Substance Name: Lanoteplase [USAN:INN]
RN: 171870-23-8
UNII: 5U26HTF8RV

Note

  • Tissue plasminogen activator in which Asn117 is replaced by Gln; reduces the area of cerebral infarction.

Molecular Formula

  • C2184-H3323-N633-O666-S29

Molecular Weight

  • 50032.9547
 

Classification Codes

  • Drug / Therapeutic Agent
  • Plasminogen Activator
  • Reproductive Effect
  • Thrombolytic
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Names and Synonyms

Name of Substance

  • Lanoteplase [USAN:INN]

Synonyms

  • (1-5)-(87-527)-Plasminogen activator (human tissue-type protein moiety), N-(N(sup 2)-(N-glycyl-L-alanyl)-L-arginyl)-117-L-glutamine-245-L-methionine
  • BMS 200980
  • BMS-200980
  • CCRIS 8593
  • Lanoteplase
  • N-(N(sup 2)-(N-Glycyl-L-alanyl)-L-arginyl)-117-L-glutamine-245-L-methionine-(1-5)-(87-527)-plasminogen activator (human tissue-type protein moiety)
  • SUN 9216
  • UNII-5U26HTF8RV

Systematic Names

  • (1-5)-(87-527)-Plasminogen activator (human tissue-type protein moiety), N-(N(sup 2))-(N-glycyl-L-alanyl)-L-arginyl)-117-L-glutamine-245-L-methionine-
  • (1-5)-(87-527)-Plasminogen activator (human tissue-type protein moiety), N-(N2-(N-glycyl-L-alanyl)-L-arginyl)-117-L-glutamine-245-L-methionine-

Registry Numbers

CAS Registry Number

  • 171870-23-8

FDA UNII

  • 5U26HTF8RV

System Generated Number

  • 0171870238

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LDLo intravenous 50mg/kg (50mg/kg) BLOOD: CHANGES IN SPLEEN

BLOOD: HEMORRHAGE

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Oyo Yakuri. Pharmacometrics. Vol. 54, Pg. 279, 1997.
rat LDLo intravenous 75600ug/kg (75.6mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

BLOOD: HEMORRHAGE
Oyo Yakuri. Pharmacometrics. Vol. 54, Pg. 279, 1997.