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Substance Name: Benzoctamine [INN:BAN]
RN: 17243-39-9
UNII: 734MM7Y191
InChIKey: GNRXCIONJWKSEA-UHFFFAOYSA-N

Molecular Formula

  • C18-H19-N

Molecular Weight

  • 249.3551
 
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Names and Synonyms

Results Name

  • Benzoctamine [INN:BAN]

Name of Substance

  • Benzoctamine
  • Benzoctamine [INN:BAN]

Synonyms

  • Benzoctamina
  • Benzoctamina [INN-Spanish]
  • Benzoctamine
  • Benzoctaminum
  • Benzoctaminum [INN-Latin]
  • Benzoktamina
  • Benzoktamina [Polish]
  • BRN 2811058
  • UNII-734MM7Y191

Systematic Names

  • 9,10-Ethanoanthracene-9(10H)-methanamine, N-methyl- (9CI)
  • 9,10-Ethanoanthracene-9(10H)-methylamine, N-methyl- (7CI,8CI)
  • Ethanoanthracene-9(10H)-methylamine, N-methyl-

Registry Numbers

CAS Registry Number

  • 17243-39-9

FDA UNII

  • 734MM7Y191

Related Registry Numbers

  • 10085-81-1 (hydrochloride)
  • 74401-28-8 (methanesulfonate)

System Generated Number

  • 0017243399

Structure Descriptors

InChI

1S/C18H19N/c1-19-12-18-11-10-13(14-6-2-4-8-16(14)18)15-7-3-5-9-17(15)18/h2-9,13,19H,10-12H2,1H3

InChIKey

GNRXCIONJWKSEA-UHFFFAOYSA-N

Smiles

CNCC12CCC(c3c1cccc3)c4c2cccc4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous > 10mg/kg (10mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 201, Pg. 25, 1973.
dog LD50 intravenous > 10mg/kg (10mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 201, Pg. 25, 1973.
dog LD50 oral > 200mg/kg (200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 201, Pg. 25, 1973.
mouse LD50 intraperitoneal 120mg/kg (120mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 40, Pg. 235, 1983.
mouse LD50 intravenous 30mg/kg (30mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 201, Pg. 25, 1973.
mouse LD50 oral 280mg/kg (280mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 201, Pg. 25, 1973.
rabbit LD50 oral 800mg/kg (800mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 201, Pg. 25, 1973.
rabbit LD90 intravenous 30mg/kg (30mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 201, Pg. 25, 1973.
rat LD50 intraperitoneal 125mg/kg (125mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 40, Pg. 235, 1983.
rat LD50 intravenous 36mg/kg (36mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 201, Pg. 25, 1973.
rat LD50 oral 600mg/kg (600mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 201, Pg. 25, 1973.
rat LD50 subcutaneous 240mg/kg (240mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 201, Pg. 25, 1973.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 3.540 (none)   EST
Atmospheric OH Rate Constant 9.13E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.