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Substance Name: Pretazettine, hydrochloride
RN: 17322-85-9
InChIKey: YHHPTRFYYPGNIO-WRDXNDLCSA-N

Note

  • A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.

Molecular Formula

  • C18-H21-N-O5.Cl-H

Molecular Weight

  • 367.827
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Synonyms

  • NSC 109808
  • Pretazettine hydrochloride
  • PTZ hydrochloride

Systematic Names

  • Pretazettine, hydrochloride
  • Tazettine, 6a-deoxy-8-hydroxy-, hydrochloride, (6a-beta,8-beta)- (9CI)

Registry Numbers

CAS Registry Number

  • 17322-85-9

System Generated Number

  • 0017322859

Molecular Formulas

Molecular Formula

  • C18-H21-N-O5.Cl-H

Molecular Formula Fragments

  • C18-H21-N-O5
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H21NO5.ClH/c1-19-8-16-18(4-3-10(21-2)5-15(18)19)12-7-14-13(22-9-23-14)6-11(12)17(20)24-16;/h3-4,6-7,10,15-17,20H,5,8-9H2,1-2H3;1H/t10-,15+,16+,17-,18+;/m1./s1

InChIKey

YHHPTRFYYPGNIO-WRDXNDLCSA-N

Smiles

Cl.C1=C[C@H](C[C@H]2[C@]31c1c(cc4c(c1)OCO4)[C@@H](O[C@H]3C[N@@]2C)O)OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 intravenous 47mg/kg (47mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

CARDIAC: PULSE RATE
Proceedings of the Western Pharmacology Society. Vol. 24, Pg. 259, 1981.