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Substance Name: Aliskiren [USAN:INN:BAN]
RN: 173334-57-1
UNII: 502FWN4Q32
InChIKey: UXOWGYHJODZGMF-QORCZRPOSA-N

Note

  • Orally active nonpeptidic renin inhibitor.

Molecular Formula

  • C30-H53-N3-O6

Molecular Weight

  • 551.7637
 

Classification Codes

  • Antihypertensive
  • Renin Inhibitor
  • Treatment of Essential Hypertension (Renin Inhibitor)

Names and Synonyms

Name of Substance

  • Aliskiren
  • Aliskiren [USAN:INN:BAN]

Synonyms

  • (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl)-2-methylpropyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonamide
  • Aliskiren
  • CGP 60536
  • CGP60536B
  • Enviage
  • HSDB 7843
  • Rasilez
  • Riprazo
  • SPP 100
  • SPP100
  • Sprimeo
  • UNII-502FWN4Q32

Systematic Names

  • 2(S),4(S),5(S),7(S)-N-(2-carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-(4-methoxy-3-(3-methoxypropoxy)phenyl)octanamid hemifumarate
  • Benzeneoctanamide, delta-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-gamma-hydroxy-4-methoxy-3-(3-methoxypropoxy)-alpha,zeta-bis-(1-methylethyl)-, (alphaS,gammaS,deltaS,zetaS)-

Mixture Name

  • Tekturna HCT

Registry Numbers

CAS Registry Number

  • 173334-57-1

FDA UNII

  • 502FWN4Q32

Other Registry Numbers

  • 401809-63-0
  • 957114-21-5

System Generated Number

  • 0173334571

Structure Descriptors

InChI

1S/C30H53N3O6/c1-19(2)22(14-21-10-11-26(38-8)27(15-21)39-13-9-12-37-7)16-24(31)25(34)17-23(20(3)4)28(35)33-18-30(5,6)29(32)36/h10-11,15,19-20,22-25,34H,9,12-14,16-18,31H2,1-8H3,(H2,32,36)(H,33,35)/t22-,23-,24-,25-/m0/s1

InChIKey

UXOWGYHJODZGMF-QORCZRPOSA-N

Smiles

COCCCOc1cc(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(=O)N)C(C)C)ccc1OC