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Substance Name: 2,3,7,8-Tetrachlorodibenzo-p-dioxin
RN: 1746-01-6
UNII: DO80M48B6O
InChIKey: HGUFODBRKLSHSI-UHFFFAOYSA-N

Note

  • A chemical by-product that results from burning or incinerating chlorinated industrial chemicals and other hydrocarbons. This compound is considered an environmental toxin, and may pose reproductive, as well as, other health risks for animals and humans.

Molecular Formula

  • C12-H4-Cl4-O2

Molecular Weight

  • 321.9736
 

Classification Codes

Classification Codes

  • Environmental Pollutants
  • Human Data
  • Mutation Data
  • Noxae
  • Reproductive Effect
  • Skin / Eye Irritant
  • Teratogens
  • Tumor Data

Superlist Classification Codes

  • 2007 CERCLA Priority List, Rank: 73
  • 2011 CERCLA Priority List, Rank: 71
  • Known to be a Human Carcinogen
  • Overall Carcinogenic Evaluation: Group 1
  • Overall Carcinogenic Evaluation: Group 2B
  • Reportable Quantity (RQ) = 1 lb

Names and Synonyms

Name of Substance

  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin
  • Tetrachlorodibenzodioxin

MeSH Heading

  • Tetrachlorodibenzodioxin

Synonyms

  • 2,3,7,8-Czterochlorodwubenzo-p-dwuoksyny
  • 2,3,7,8-Czterochlorodwubenzo-p-dwuoksyny [Polish]
  • 2,3,7,8-TCDD
  • 2,3,7,8-Tetra polychlorinated dibenzo-p-dioxin
  • 2,3,7,8-Tetrachlorodibenzo(b,e)(1,4)dioxin
  • 2,3,7,8-Tetrachlorodibenzo-1,4-dioxin
  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin
  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin [Dioxin and dioxin-like compounds]
  • 2,3,7,8-Tetrachlorodibenzodioxin
  • 5-19-02-00041 (Beilstein Handbook Reference)
  • BRN 0271116
  • CCRIS 576
  • Dibenzo(b,e)(1,4)dioxin, 2,3,7,8-tetrachloro-
  • Dibenzo-p-dioxin, 2,3,7,8-tetrachloro-
  • Dioksyny
  • Dioksyny [Polish]
  • Dioxin
  • Dioxin (herbicide contaminant)
  • Dioxine
  • EINECS 217-122-7
  • HSDB 4151
  • NCI-C03714
  • TCDBD
  • TCDD
  • Tetrachlorodibenzo-p-dioxin
  • Tetrachlorodibenzodioxin
  • Tetradioxin
  • UNII-DO80M48B6O

Systematic Names

  • 2,3,7,8-Tetrachlorodibenzo(b,e)(1,4)dioxin
  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin
  • Dibenzo(b,e)(1,4)dioxin, 2,3,7,8-tetrachloro-
  • Dibenzo-p-dioxin, 2,3,7,8-tetrachloro-

Superlist Names

  • 2,3,7,8-Tetrachlorodibenzo(b,e)(1,4)dioxin
  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin
  • Dibenzo(b,e)(1,4)dioxin, 2,3,7,8-tetrachloro-
  • Dioxin
  • TCDD

Registry Numbers

CAS Registry Number

  • 1746-01-6

FDA UNII

  • DO80M48B6O

Other Registry Number

  • 56795-67-6

System Generated Number

  • 0001746016

Structure Descriptors

InChI

1S/C12H4Cl4O2/c13-5-1-9-10(2-6(5)14)18-12-4-8(16)7(15)3-11(12)17-9/h1-4H

InChIKey

HGUFODBRKLSHSI-UHFFFAOYSA-N

Smiles

c1c2c(cc(c1Cl)Cl)Oc3cc(c(cc3O2)Cl)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LDLo intraperitoneal 25ug/kg (0.025mg/kg)   Journal of Toxicology and Environmental Health. Vol. 35, Pg. 187, 1992.
chicken LDLo intraperitoneal 25ug/kg (0.025mg/kg)   Journal of Toxicology and Environmental Health. Vol. 35, Pg. 187, 1992.
chicken LDLo intraperitoneal 25ug/kg (0.025mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL) Journal of Toxicology and Environmental Health. Vol. 35, Pg. 187, 1992.
chicken LDLo oral 25ug/kg (0.025mg/kg)   Food and Cosmetics Toxicology. Vol. 11, Pg. 585, 1973.
chicken LDLo oral 25ug/kg (0.025mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Food and Cosmetics Toxicology. Vol. 11, Pg. 585, 1973.
dog LD50 oral 1ug/kg (0.001mg/kg)   Experientia. Vol. 38, Pg. 879, 1982.
frog LD50 oral 1mg/kg (1mg/kg)   Scientific American. Vol. 254, Pg. 29, 1986.
guinea pig LD50 oral 500ng/kg (0.0005mg/kg)   Environmental Science Research. Vol. 2, Pg. 708, 1973.
hamster LD50 intraperitoneal > 3mg/kg (3mg/kg) ENDOCRINE: CHANGES IN THYMUS WEIGHT

BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"		 Toxicology and Applied Pharmacology. Vol. 55, Pg. 67, 1980.
hamster LD50 oral 1157ug/kg (1.157mg/kg)   Toxicology and Applied Pharmacology. Vol. 55, Pg. 67, 1980.
hamster LD50 oral 1157ug/kg (1.157mg/kg) BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"

GASTROINTESTINAL: OTHER CHANGES		 Toxicology and Applied Pharmacology. Vol. 55, Pg. 67, 1980.
human TDLo skin 107ug/kg (0.107mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER TOPICAL EXPOSURE" Scientific American. Vol. 254, Pg. 29, 1986.
mammal (species unspecified) LD50 oral 4200ng/kg (0.0042mg/kg) BLOOD: CHANGES IN SPLEEN

KIDNEY, URETER, AND BLADDER: OTHER CHANGES

LIVER: OTHER CHANGES		 Archives of Environmental Contamination and Toxicology. Vol. 17, Pg. 33, 1988.
monkey LD50 oral 2ug/kg (0.002mg/kg)   Experientia. Vol. 38, Pg. 879, 1982.
mouse LD50 intraperitoneal 120ug/kg (0.12mg/kg)   Scientific American. Vol. 254, Pg. 29, 1986.
mouse LD50 oral 114ug/kg (0.114mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

CARDIAC: OTHER CHANGES		 Toxicology and Applied Pharmacology. Vol. 29, Pg. 229, 1974.
mouse LDLo skin 80ug/kg (0.08mg/kg) GASTROINTESTINAL: OTHER CHANGES Research Communications in Chemical Pathology and Pharmacology. Vol. 20, Pg. 101, 1978.
mouse LDLo unreported 200ug/kg (0.2mg/kg)   Annals of the New York Academy of Sciences. Vol. 320, Pg. 204, 1979.
mouse LDLo unreported 200ug/kg (0.2mg/kg) LIVER: FATTY LIVER DEGERATION Annals of the New York Academy of Sciences. Vol. 320, Pg. 204, 1979.
rabbit LD50 intraperitoneal 252ug/kg (0.252mg/kg)   Scientific American. Vol. 254, Pg. 29, 1986.
rabbit LD50 oral 115ug/kg (0.115mg/kg)   Toxicology and Applied Pharmacology. Vol. 35, Pg. 553, 1976.
rabbit LD50 skin 275ug/kg (0.275mg/kg)   EHP, Environmental Health Perspectives. Vol. 5, Pg. 87, 1973.
rat LD50 intraperitoneal 24600ng/kg (0.0246mg/kg)   Toxicology and Applied Pharmacology. Vol. 45, Pg. 513, 1978.
rat LD50 oral 20ug/kg (0.02mg/kg)   Experientia. Vol. 38, Pg. 879, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 305 deg C   EXP
log P (octanol-water) 6.8 (none)   EXP
Water Solubility 2.00E-04 mg/L 25 EXP
Vapor Pressure 1.50E-09 mm Hg 25 EXP
Henry's Law Constant 5.00E-05 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 7.53E-13 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.