Substance Name: Rituximab [USAN:INN:BAN]
RN: 174722-31-7
UNII: 4F4X42SYQ6
Notes
- A genetically engineered anti-CD20 antibody for the treatment of B-cell lymphoma.
NCI: A recombinant chimeric murine/human antibody directed against the CD20 antigen, a hydrophobic transmembrane protein located on normal pre-B and mature B lymphocytes. Following binding, rituximab triggers a host cytotoxic immune response against CD20-positive cells.(NCI Dictionary) - A murine-derived monoclonal antibody and ANTINEOPLASTIC AGENT that binds specifically to the CD20 ANTIGEN and is used in the treatment of LEUKEMIA; LYMPHOMA and RHEUMATOID ARTHRITIS.
Molecular Formulas
- C6416-H9874-N1688-O1987-S44
- Unspecified
Classification Codes
- Antineoplastic
- Antineoplastic (Microtubule Inhibitor)
- Antineoplastic Agents
- Antineoplastic Agents, Immunological
- Antirheumatic Agents
- Immunologic Factors
- Microtubule Inhibitor
- Monoclonal Antibody
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Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Names and Synonyms
Name of Substance
- Rituximab
- Rituximab [USAN:INN:BAN]
MeSH Heading
- Rituximab
Synonyms
- HSDB 7455
- IDEC-102
- IDEC-C2B8
- Immunoglobulin G 1 (human-mouse monoclonal IDEC-C2B8 gamma1-chain anti-human antigen CD 20), disulfide with human-mouse monoclonal IDEC-C2B8 kappa-chain, dimer
- Immunoglobulin G 1 (human-mouse monoclonal IDEC-C2B8 gamma1-chain anti-human antigen CD 20), disulfide with human-mouse monoclonal IDEC-C2B8 kappa-chain, dimer. Molecular weight is approximately 144,187 daltons
- Mab Thera
- MabThera
- PF 05280586
- PF-05280586
- Rituxan
- Rituximab
- UNII-4F4X42SYQ6
Systematic Name
- Immunoglobulin G1, anti-(human CD20 (antigen)(human-mouse monoclonal IDEC-C2B8 gamma1-chain), disulfide with human-mouse monoclonal IDEC-C2B8 kappa-chain, dimer
Registry Numbers
CAS Registry Number
- 174722-31-7
FDA UNII
- 4F4X42SYQ6
System Generated Number
- 0174722317