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Substance Name: Rituximab [USAN:INN:BAN]
RN: 174722-31-7
UNII: 4F4X42SYQ6

Notes

  • A genetically engineered anti-CD20 antibody for the treatment of B-cell lymphoma.

    NCI: A recombinant chimeric murine/human antibody directed against the CD20 antigen, a hydrophobic transmembrane protein located on normal pre-B and mature B lymphocytes. Following binding, rituximab triggers a host cytotoxic immune response against CD20-positive cells.(NCI Dictionary)
  • A murine-derived monoclonal antibody and ANTINEOPLASTIC AGENT that binds specifically to the CD20 ANTIGEN and is used in the treatment of LEUKEMIA; LYMPHOMA and RHEUMATOID ARTHRITIS.

Molecular Formulas

  • C6416-H9874-N1688-O1987-S44
  • Unspecified
 

Classification Codes

  • Antineoplastic
  • Antineoplastic (Microtubule Inhibitor)
  • Antineoplastic Agents
  • Antineoplastic Agents, Immunological
  • Antirheumatic Agents
  • Immunologic Factors
  • Microtubule Inhibitor
  • Monoclonal Antibody

Names and Synonyms

Name of Substance

  • Rituximab
  • Rituximab [USAN:INN:BAN]

MeSH Heading

  • Rituximab

Synonyms

  • HSDB 7455
  • IDEC-102
  • IDEC-C2B8
  • Immunoglobulin G 1 (human-mouse monoclonal IDEC-C2B8 gamma1-chain anti-human antigen CD 20), disulfide with human-mouse monoclonal IDEC-C2B8 kappa-chain, dimer
  • Immunoglobulin G 1 (human-mouse monoclonal IDEC-C2B8 gamma1-chain anti-human antigen CD 20), disulfide with human-mouse monoclonal IDEC-C2B8 kappa-chain, dimer. Molecular weight is approximately 144,187 daltons
  • Mab Thera
  • MabThera
  • PF 05280586
  • PF-05280586
  • Rituxan
  • Rituximab
  • UNII-4F4X42SYQ6

Systematic Name

  • Immunoglobulin G1, anti-(human CD20 (antigen)(human-mouse monoclonal IDEC-C2B8 gamma1-chain), disulfide with human-mouse monoclonal IDEC-C2B8 kappa-chain, dimer

Registry Numbers

CAS Registry Number

  • 174722-31-7

FDA UNII

  • 4F4X42SYQ6

System Generated Number

  • 0174722317