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Substance Name: Flurazepam [INN:BAN:JAN]
RN: 17617-23-1
UNII: IHP475989U
InChIKey: SAADBVWGJQAEFS-UHFFFAOYSA-N

Note

  • A benzodiazepine derivative used mainly as a hypnotic.

Molecular Formula

  • C21-H23-Cl-F-N3-O

Molecular Weight

  • 387.8837
 

Classification Codes

Classification Codes

  • Anti-Anxiety Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • GABA Agents
  • GABA Modulators
  • Human Data
  • Hypnotics and Sedatives
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Reproductive Effect
  • Tranquilizing Agents

Superlist Classification Code

  • DEA Schedule IV

Names and Synonyms

Name of Substance

  • Flurazepam
  • Flurazepam [INN:BAN:JAN]

MeSH Heading

  • Flurazepam

Synonyms

  • 5-24-04-00322 (Beilstein Handbook Reference)
  • 7-Chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • 7-Chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2(3H)-one
  • BRN 0767925
  • Dalmane-R
  • EINECS 241-591-7
  • Flurazepam
  • Flurazepamum
  • Flurazepamum [INN-Latin]
  • HSDB 3085
  • Ro-5-6901/3
  • UNII-IHP475989U

Systematic Names

  • 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluorophenyl)-
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-
  • Flurazepam

Superlist Names

  • DEA No. 2767
  • Flurazepam

Registry Numbers

CAS Registry Number

  • 17617-23-1

FDA UNII

  • IHP475989U

Related Registry Numbers

  • 1172-18-5 (di-hydrochloride)
  • 36105-20-1 (mono-hydrochloride)

System Generated Number

  • 0017617231

Structure Descriptors

InChI

1S/C21H23ClFN3O/c1-3-25(4-2)11-12-26-19-10-9-15(22)13-17(19)21(24-14-20(26)27)16-7-5-6-8-18(16)23/h5-10,13H,3-4,11-12,14H2,1-2H3

InChIKey

SAADBVWGJQAEFS-UHFFFAOYSA-N

Smiles

CCN(CC)CCN1c2ccc(cc2C(=NCC1=O)c3ccccc3F)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo oral 250mg/kg (250mg/kg)   Drugs of the Future. Vol. 9, Pg. 152, 1984.
human TDLo oral 380ug/kg (0.38mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
American Journal of Medicine. Vol. 73, Pg. 239, 1982.
mouse LD50 intraperitoneal 540mg/kg (540mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977.
mouse LD50 intravenous 59100ug/kg (59.1mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975.
mouse LD50 oral 500mg/kg (500mg/kg)   Therapie. Vol. 26, Pg. 439, 1971.
mouse LD50 subcutaneous 3844mg/kg (3844mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977.
rat LD50 intraperitoneal 600mg/kg (600mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977.
rat LD50 intravenous 38700ug/kg (38.7mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 530, 1975.
rat LD50 oral 980mg/kg (980mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977.
rat LD50 subcutaneous > 3844mg/kg (3844mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 79.5 deg C   EXP
log P (octanol-water) 3.020 (none)   EST
Atmospheric OH Rate Constant 1.07E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.