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Substance Name: Bucinnazine hydrochloride
RN: 17730-82-4
UNII: G74ME71CIT
InChIKey: HPGCBEMVWCCLIT-AAGWESIMSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C17-H24-N2-O.Cl-H

Molecular Weight

  • 308.85
 
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Names and Synonyms

Name of Substance

  • Bucinnazine hydrochloride

Synonyms

  • 1-Butyryl-4-(phenylallyl)piperazine hydrochloride
  • 1-Butyryl-4-cinnamylpiperazine
  • 1-Butyryl-4-cinnamylpiperazine hydrochloride
  • 1-n-Butyryl-4-cinnamyl piperazine hydrochloride
  • AP-237
  • P 237
  • Piperazine, 1-butyryl-4-(phenylallyl)-, hydrochloride
  • UNII-G74ME71CIT

Systematic Name

  • Piperazine, 1-butyryl-4-cinnamyl-, hydrochloride

Registry Numbers

CAS Registry Number

  • 17730-82-4

FDA UNII

  • G74ME71CIT

Related Registry Number

  • 17719-89-0 (Parent)

System Generated Number

  • 0017730824

Molecular Formulas

Molecular Formula

  • C17-H24-N2-O.Cl-H

Molecular Formula Fragments

  • C17-H24-N2-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H24N2O.ClH/c1-2-7-17(20)19-14-12-18(13-15-19)11-6-10-16-8-4-3-5-9-16;/h3-6,8-10H,2,7,11-15H2,1H3;1H/b10-6+;

InChIKey

HPGCBEMVWCCLIT-AAGWESIMSA-N

Smiles

N1(C(=O)CCC)CCN(C\C=C\c2ccccc2)CC1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral 260mg/kg (260mg/kg)   Toxicology and Applied Pharmacology. Vol. 25, Pg. 443, 1973.
guinea pig LD50 oral 700mg/kg (700mg/kg) BEHAVIORAL: ANALGESIA Japanese Journal of Pharmacology. Vol. 20, Pg. 287, 1970.
guinea pig LDLo subcutaneous 400mg/kg (400mg/kg)   Toxicology and Applied Pharmacology. Vol. 25, Pg. 443, 1973.
mouse LD50 intravenous 80800ug/kg (80.8mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 173, 1972.
mouse LD50 oral 710mg/kg (710mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ANALGESIA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 213, Pg. 28, 1975.
mouse LD50 subcutaneous 258mg/kg (258mg/kg) BEHAVIORAL: ANALGESIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 213, Pg. 28, 1975.
rat LD50 intravenous 70mg/kg (70mg/kg) BEHAVIORAL: ANALGESIA Japanese Journal of Pharmacology. Vol. 20, Pg. 287, 1970.
rat LD50 oral 545mg/kg (545mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ANALGESIA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 213, Pg. 28, 1975.
rat LD50 subcutaneous 339mg/kg (339mg/kg) BEHAVIORAL: ANALGESIA Japanese Journal of Pharmacology. Vol. 20, Pg. 287, 1970.