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Substance Name: Clonixin [USAN:INN]
RN: 17737-65-4
UNII: V7DXN0M42R
InChIKey: CLOMYZFHNHFSIQ-UHFFFAOYSA-N

Note

  • Anti-inflammatory analgesic.

Molecular Formula

  • C13-H11-Cl-N2-O2

Molecular Weight

  • 262.6949
 

Classification Codes

  • Analgesic
  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Clonixin
  • Clonixin [USAN:INN]

MeSH Heading

  • Clonixin

Synonyms

  • 2-(2'-Methyl-3'-chloro)anilinonicotinic acid
  • 2-(3-Chloro-2-methylanilino)nicotinic acid
  • 2-(3-Chloro-o-toluidino)nicotinic acid
  • 3-Pyridinecarboxylic acid, 2-((3-chloro-2-methylphenyl)amino)-
  • 5-22-13-00597 (Beilstein Handbook Reference)
  • BRN 0483212
  • CBA 93626
  • Clonix
  • Clonixic acid
  • Clonixin
  • Clonixine
  • Clonixine [INN-French]
  • Clonixino
  • Clonixino [INN-Spanish]
  • Clonixinum
  • Clonixinum [INN-Latin]
  • Deltar
  • EINECS 241-730-1
  • NSC 335505
  • Sch 10304
  • UNII-V7DXN0M42R

Systematic Names

  • 3-Pyridinecarboxylic acid, 2-((3-chloro-2-methylphenyl)amino)-
  • Clonixin
  • Nicotinic acid, 2-(3-chloro-o-toluidino)-

Registry Numbers

CAS Registry Number

  • 17737-65-4

FDA UNII

  • V7DXN0M42R

System Generated Number

  • 0017737654

Structure Descriptors

InChI

1S/C13H11ClN2O2/c1-8-10(14)5-2-6-11(8)16-12-9(13(17)18)4-3-7-15-12/h2-7H,1H3,(H,15,16)(H,17,18)

InChIKey

CLOMYZFHNHFSIQ-UHFFFAOYSA-N

Smiles

Cc1c(cccc1Cl)Nc2c(cccn2)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 198mg/kg (198mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 655, 1973.
mouse LD50 oral 400mg/kg (400mg/kg) BEHAVIORAL: ATAXIA

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 655, 1973.
mouse LD50 subcutaneous 263mg/kg (263mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 655, 1973.
rat LD50 intraperitoneal 148mg/kg (148mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 655, 1973.
rat LD50 oral 335mg/kg (335mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 655, 1973.
rat LD50 subcutaneous 325mg/kg (325mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 655, 1973.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 234 deg C   EXP
log P (octanol-water) 4.580 (none)   EST
Atmospheric OH Rate Constant 1.37E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.