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Substance Name: Mepixanox [INN]
RN: 17854-59-0
UNII: 7419T4YQQW
InChIKey: PYSOHOOUXFWCFF-UHFFFAOYSA-N

Note

  • Respiratory analeptic.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C20-H21-N-O3

Molecular Weight

  • 323.39
 
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Names and Synonyms

Name of Substance

  • Mepixanox
  • Mepixanox [INN]
  • Pimexone

Synonyms

  • 3-Methoxy-4-(1-piperidinylmethyl)-9H-xanthen-9-one
  • 3-Methoxy-4-(piperidinomethyl)-xanthen-9-one
  • 5-20-03-00406 (Beilstein Handbook Reference)
  • BRN 1296265
  • EINECS 241-810-6
  • Mepixanox
  • Mepixanoxum
  • Mepixanoxum [Latin]
  • Mepixanthone
  • Pimexone
  • UNII-7419T4YQQW

Systematic Names

  • 3-Methoxy-4-(piperidinomethyl)xanthen-9-one
  • 9H-Xanthen-9-one, 3-methoxy-4-(1-piperidinylmethyl)-
  • Mepixanox
  • Xanthen-9-one, 3-methoxy-4-(piperidinomethyl)- (8CI)-

Registry Numbers

CAS Registry Number

  • 17854-59-0

FDA UNII

  • 7419T4YQQW

Related Registry Number

  • 17854-76-1 (hydrochloride)

System Generated Number

  • 0017854590

Structure Descriptors

InChI

1S/C20H21NO3/c1-23-17-10-9-15-19(22)14-7-3-4-8-18(14)24-20(15)16(17)13-21-11-5-2-6-12-21/h3-4,7-10H,2,5-6,11-13H2,1H3

InChIKey

PYSOHOOUXFWCFF-UHFFFAOYSA-N

Smiles

c1c2c(=O)c3ccc(c(CN4CCCCC4)c3oc2ccc1)OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intraperitoneal 89mg/kg (89mg/kg)   Medicamentos de Actualidad. Vol. 24, Pg. 15, 1988.
mouse LD50 intraperitoneal 70730ug/kg (70.73mg/kg)   South African Patent Document. Vol. #69/2150,
mouse LD50 intravenous 16mg/kg (16mg/kg)   Medicamentos de Actualidad. Vol. 24, Pg. 15, 1988.
mouse LD50 oral 161mg/kg (161mg/kg)   Medicamentos de Actualidad. Vol. 24, Pg. 15, 1988.
rabbit LD50 intraperitoneal 53mg/kg (53mg/kg)   Medicamentos de Actualidad. Vol. 24, Pg. 15, 1988.
rabbit LD50 intravenous 15600ug/kg (15.6mg/kg)   Medicamentos de Actualidad. Vol. 24, Pg. 15, 1988.
rat LD50 intraperitoneal 49mg/kg (49mg/kg)   Medicamentos de Actualidad. Vol. 24, Pg. 15, 1988.
rat LD50 intravenous 18mg/kg (18mg/kg)   Medicamentos de Actualidad. Vol. 24, Pg. 15, 1988.
rat LD50 oral 183mg/kg (183mg/kg)   Medicamentos de Actualidad. Vol. 24, Pg. 15, 1988.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 159.5 deg C   EXP
log P (octanol-water) 5.040 (none)   EST
Atmospheric OH Rate Constant 1.66E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.