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Substance Name: Prilocaine hydrochloride [USAN:USP]
RN: 1786-81-8
UNII: MJW015BAPH
InChIKey: BJPJNTKRKALCPP-UHFFFAOYSA-N
Note
- A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165)
Molecular Formula
- C13-H20-N2-O.Cl-H
Molecular Weight
- 256.7749
- All
- Classifications
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- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Anesthetic (Local)
- Drug / Therapeutic Agent
- Human Data
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Names and Synonyms
Name of Substance
- Prilocaine hydrochloride [USAN:USP]
Synonyms
- 2-(Propylamino)-o-propionotoluidide hydrochloride
- 2-(Propylamino)-o-propionotoluidide monohydrochloride
- alpha-Propylamine-2-methyl-propionanilide hydrochloride
- Astra 1512
- Citanest
- Citanest hydrochloride
- Citanest Plain
- EINECS 217-244-0
- L-67
- NSC 758432
- Prilocaine chloride
- Prilocaine HCl
- Prilocaine hydrochloride
- Propanamide, N-(2-methylphenyl)-2-(propylamino)-, monohydrochloride
- Propitocaine hydrochloride
- UNII-MJW015BAPH
- Xylonest
Systematic Names
- o-Propionotoluidide, 2-(propylamino)-, monohydrochloride
- Prilocaine hydrochloride
- Propanamide, N-(2-methylphenyl)-2-(propylamino)-, monohydrochloride
Mixture Name
- Citanest forte
Registry Numbers
CAS Registry Number
- 1786-81-8
FDA UNII
- MJW015BAPH
System Generated Number
- 0001786818
Molecular Formulas
Molecular Formula
- C13-H20-N2-O.Cl-H
Molecular Formula Fragments
- C13-H20-N2-O
- Cl-H
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C13H20N2O.ClH/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2;/h5-8,11,14H,4,9H2,1-3H3,(H,15,16);1HInChIKey
BJPJNTKRKALCPP-UHFFFAOYSA-NSmiles
Cl.CCCNC(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | LDLo | parenteral | 12343ug/kg/1H (12.343mg/kg) | BLOOD: HEMORRHAGE | Journal of Analytical Toxicology. Vol. 10, Pg. 75, 1986. |
mouse | LD50 | intraperitoneal | 30mg/kg (30mg/kg) | "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969. | |
mouse | LD50 | intravenous | 55mg/kg (55mg/kg) | Drugs in Japan Vol. 6, Pg. 692, 1982. | |
mouse | LD50 | subcutaneous | 632mg/kg (632mg/kg) | Drugs in Japan Vol. 6, Pg. 692, 1982. | |
rabbit | LD50 | intratracheal | 65mg/kg (65mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Journal of Pharmacology and Experimental Therapeutics. Vol. 132, Pg. 87, 1961. |
rabbit | LD50 | intravenous | 18mg/kg (18mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 132, Pg. 87, 1961. |
rat | LD50 | intraperitoneal | 148mg/kg (148mg/kg) | Drugs in Japan Vol. 6, Pg. 692, 1982. | |
rat | LD50 | intravenous | 56600ug/kg (56.6mg/kg) | Drugs in Japan Vol. 6, Pg. 692, 1982. | |
rat | LD50 | subcutaneous | 790mg/kg (790mg/kg) | Drugs in Japan Vol. 6, Pg. 692, 1982. |