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Substance Name: Fentiazac [USAN:INN:BAN:JAN]
RN: 18046-21-4
UNII: 0YHF6E6NLS
InChIKey: JIEKMACRVQTPRC-UHFFFAOYSA-N

Molecular Formula

  • C17-H12-Cl-N-O2-S

Molecular Weight

  • 329.806
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Fentiazac
  • Fentiazac [USAN:INN:BAN:JAN]

Synonyms

  • 4-(4-Chlorophenyl)-2-phenyl-5-thiazoleacetic acid
  • 4-(p-Chlorophenyl)-2-phenyl-5-thiazoleacetic acid
  • BR 700
  • BRN 1083610
  • CH 800
  • Donorest
  • EINECS 241-958-1
  • Fentiazac
  • Fentiazaco
  • Fentiazaco [INN-Spanish]
  • Fentiazacum
  • Fentiazacum [INN-Latin]
  • Flogene
  • Norvedan
  • NSC 282191
  • UNII-0YHF6E6NLS
  • WY 21,894
  • WY-21,894

Systematic Names

  • 5-Thiazoleacetic acid, 4-(4-chlorophenyl)-2-phenyl-
  • 5-Thiazoleacetic acid, 4-(p-chlorophenyl)-2-phenyl-
  • Fentiazac

Registry Numbers

CAS Registry Number

  • 18046-21-4

FDA UNII

  • 0YHF6E6NLS

System Generated Number

  • 0018046214

Structure Descriptors

InChI

1S/C17H12ClNO2S/c18-13-8-6-11(7-9-13)16-14(10-15(20)21)22-17(19-16)12-4-2-1-3-5-12/h1-9H,10H2,(H,20,21)

InChIKey

JIEKMACRVQTPRC-UHFFFAOYSA-N

Smiles

c1(c(sc(n1)c1ccccc1)CC(O)=O)c1ccc(Cl)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 103mg/kg (103mg/kg) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1895, 1979.
mouse LD50 intraperitoneal 385mg/kg (385mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1895, 1979.
mouse LD50 intravenous 161mg/kg (161mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1895, 1979.
mouse LD50 oral 520mg/kg (520mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1895, 1979.
mouse LD50 subcutaneous 655mg/kg (655mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1895, 1979.
rabbit LD50 intravenous 71mg/kg (71mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1895, 1979.
rabbit LD50 oral 625mg/kg (625mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1895, 1979.
rat LD50 intraperitoneal 325mg/kg (325mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1895, 1979.
rat LD50 intravenous 160mg/kg (160mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1895, 1979.
rat LD50 oral 409mg/kg (409mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1895, 1979.
rat LD50 subcutaneous 543mg/kg (543mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 1895, 1979.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 161.5 deg C   EXP
pKa Dissociation Constant 3.6 (none)   EXP
log P (octanol-water) 5.19 (none)   EXP
Water Solubility 3.58 mg/L 25 EXP
Vapor Pressure 1.70E-10 mm Hg 25 EST
Henry's Law Constant 1.37E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 7.00E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.