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Substance Name: Butamirate citrate [USAN]
RN: 18109-81-4
UNII: 67HP51L98R
InChIKey: JVKMHUAWFDGPTF-UHFFFAOYSA-N

Classification Codes

  • Antitussive
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C18-H29-N-O3.C6-H8-O7

Molecular Weight

  • 499.553
 
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Names and Synonyms

Name of Substance

  • Butamirate
  • Butamirate citrate
  • Butamirate citrate [USAN]

Synonyms

  • 2-(2-(Diethylamino)ethoxy)-ethyl 2-phenylbutyrate citrate
  • 2-(2-(Diethylamino)ethoxy)ethyl 2-phenylbutyrate citrate (1:1)
  • 2-Phenylbutyric acid 2-(2-(diethylamino)ethoxy)ethyl ester citrate
  • Abbott 36581
  • Abbott-36581
  • Acodeen
  • alpha-Ethylbenzeneacetic acid 2-(2-(diethylamino)ethoxy)ethyl ester citrate
  • Benzeneacetic acid, alpha-ethyl-2-(2-(diethylamino)ethoxy)ethyl ester, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
  • Butamirate citrate
  • Butamyrate citrate
  • EINECS 242-006-8
  • HH 197
  • HH-197
  • Phenyl acetic acid diethylaminoethoxyethanol ester citrate
  • Sincodeen
  • Sincodex
  • Sincodin
  • Sincodix
  • Sinecod
  • UNII-67HP51L98R

Systematic Names

  • alpha-Ethylbenzeneacetic acid, 2-(2-(diethylamino)ethoxy)ethyl ester, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
  • Benzeneacetic acid, alpha-ethyl-2-(2-(diethylamino)ethoxy)ethyl ester, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
  • Butyric acid, 2-phenyl-, 2-(2-(diethylamino)ethoxy)ethyl ester, citrate
  • Diethyl(2-(2-(2-phenylbutyroyloxy)ethoxy)ethyl)ammonium dihydrogencitrate

Registry Numbers

CAS Registry Number

  • 18109-81-4

FDA UNII

  • 67HP51L98R

System Generated Number

  • 0018109814

Molecular Formulas

Molecular Formula

  • C18-H29-N-O3.C6-H8-O7

Molecular Formula Fragments

  • C18-H29-N-O3
  • C6-H8-O7
  • COMPONENT

Structure Descriptors

InChI

1S/C18H29NO3.C6H8O7/c1-4-17(16-10-8-7-9-11-16)18(20)22-15-14-21-13-12-19(5-2)6-3;7-3(8)1-6(13,5(11)12)2-4(9)10/h7-11,17H,4-6,12-15H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChIKey

JVKMHUAWFDGPTF-UHFFFAOYSA-N

Smiles

c1([C@@H](C(OCCOCCN(CC)CC)=O)CC)ccccc1.C(CC(CC(O)=O)(O)C(=O)O)(O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 47200ug/kg (47.2mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 18, Pg. 115, 1971.
mouse LD50 oral 865mg/kg (865mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 18, Pg. 115, 1971.
mouse LD50 subcutaneous 635mg/kg (635mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 18, Pg. 115, 1971.
rat LD50 intravenous 37200ug/kg (37.2mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 18, Pg. 115, 1971.
rat LD50 oral 4164mg/kg (4164mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 18, Pg. 115, 1971.
rat LD50 subcutaneous 3638mg/kg (3638mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 18, Pg. 115, 1971.