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Substance Name: Bromazepam [USAN:INN:BAN:JAN]
RN: 1812-30-2
UNII: X015L14V0O
InChIKey: VMIYHDSEFNYJSL-UHFFFAOYSA-N

Note

  • One of the BENZODIAZEPINES that is used in the treatment of ANXIETY DISORDERS.

Molecular Formula

  • C14-H10-Br-N3-O

Molecular Weight

  • 316.157
 

Classification Codes

Classification Codes

  • Anti-Anxiety Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • GABA Agents
  • GABA Modulators
  • Mutation Data
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tranquilizer (Minor)
  • Tranquilizing Agents

Superlist Classification Code

  • DEA Schedule IV
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Names and Synonyms

Name of Substance

  • Bromazepam
  • Bromazepam [USAN:INN:BAN:JAN]

MeSH Heading

  • Bromazepam

Synonyms

  • 1,3-Dihydro-7-bromo-5-(2-pyridyl)-2H-1,4-benzodiazepin-2-one
  • 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-bromo-5-(2-pyridyl)-
  • 5-26-05-00078 (Beilstein Handbook Reference)
  • 7-Bromo-1,3-dihydro-5-(2-pyridyl)-2H-1,4-benzdiazepin-2-one
  • 7-Bromo-1,3-dihydro-5-(2-pyridyl)-2H-1,4-benzodiazepin-2-one
  • 7-Bromo-5-(2-pyridyl)-3H-1,4-benzodiazepin-2(1H)-one
  • BRN 0618645
  • Bromazepam
  • Bromazepamum
  • Bromazepamum [INN-Latin]
  • Bromazepamum [Latin]
  • Calmepam
  • Compedium
  • Compendium
  • Creosedin
  • Durazanil
  • EINECS 217-322-4
  • KL 001
  • KL-001
  • LA Xvii
  • Lectopam
  • Lekotam
  • Lexaurin
  • Lexilium
  • Lexomil
  • Lexotan
  • Lexotanil
  • Normoc
  • NSC 140669
  • Pasca;oi,
  • Ro 5-3350
  • Ultramidol
  • UNII-X015L14V0O

Systematic Names

  • 2H-1,4-Benzodiazepin-2-one, 7-bromo-1,3-dihydro-5-(2-pyridinyl)-
  • 2H-1,4-Benzodiazepin-2-one, 7-bromo-1,3-dihydro-5-(2-pyridyl)-
  • Bromazepam

Superlist Names

  • Bromazepam
  • DEA No. 2748

Registry Numbers

CAS Registry Number

  • 1812-30-2

FDA UNII

  • X015L14V0O

Other Registry Number

  • 37355-30-9

System Generated Number

  • 0001812302

Structure Descriptors

InChI

InChI=1S/C14H10BrN3O/c15-9-4-5-11-10(7-9)14(17-8-13(19)18-11)12-3-1-2-6-16-12/h1-7H,8H2,(H,18,19)

InChIKey

VMIYHDSEFNYJSL-UHFFFAOYSA-N

Smiles

Brc1ccc2NC(=O)CN=C(c3ccccn3)c2c1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 200mg/kg (200mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Journal of Drug Research. Vol. 16, Pg. 7, 1985.
mouse LD50 oral 879mg/kg (879mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 115, 1979.
mouse LD50 rectal > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 1048, 1990.
mouse LD50 subcutaneous 6870mg/kg (6870mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 115, 1979.
rabbit LD50 oral 1690mg/kg (1690mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 158, 1972.
rat LD50 intraperitoneal 1660mg/kg (1660mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 115, 1979.
rat LD50 oral 1950mg/kg (1950mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)		 Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2413, 1973.
rat LD50 rectal > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 1048, 1990.
rat LD50 subcutaneous 8800mg/kg (8800mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 115, 1979.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 2.05 (none)   EXP
Water Solubility 175 mg/L 25 EST
Vapor Pressure 1.90E-09 mm Hg 25 EST
Henry's Law Constant 1.25E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 5.79E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.