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Substance Name: Bromazepam [USAN:INN:BAN:JAN]
RN: 1812-30-2
UNII: X015L14V0O
InChIKey: VMIYHDSEFNYJSL-UHFFFAOYSA-N
Note
- One of the BENZODIAZEPINES that is used in the treatment of ANXIETY DISORDERS.
Molecular Formula
- C14-H10-Br-N3-O
Molecular Weight
- 316.157
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Anti-Anxiety Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- GABA Agents
- GABA Modulators
- Mutation Data
- Neurotransmitter Agents
- Psychotropic Drugs
- Reproductive Effect
- Skin / Eye Irritant
- Tranquilizer (Minor)
- Tranquilizing Agents
Superlist Classification Code
- DEA Schedule IV
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NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
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Names and Synonyms
Name of Substance
- Bromazepam
- Bromazepam [USAN:INN:BAN:JAN]
MeSH Heading
- Bromazepam
Synonyms
- 1,3-Dihydro-7-bromo-5-(2-pyridyl)-2H-1,4-benzodiazepin-2-one
- 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-bromo-5-(2-pyridyl)-
- 5-26-05-00078 (Beilstein Handbook Reference)
- 7-Bromo-1,3-dihydro-5-(2-pyridyl)-2H-1,4-benzdiazepin-2-one
- 7-Bromo-1,3-dihydro-5-(2-pyridyl)-2H-1,4-benzodiazepin-2-one
- 7-Bromo-5-(2-pyridyl)-3H-1,4-benzodiazepin-2(1H)-one
- BRN 0618645
- Bromazepam
- Bromazepamum
- Bromazepamum [INN-Latin]
- Bromazepamum [Latin]
- Calmepam
- Compedium
- Compendium
- Creosedin
- Durazanil
- EINECS 217-322-4
- KL 001
- KL-001
- LA Xvii
- Lectopam
- Lekotam
- Lexaurin
- Lexilium
- Lexomil
- Lexotan
- Lexotanil
- Normoc
- NSC 140669
- Pasca;oi,
- Ro 5-3350
- Ultramidol
- UNII-X015L14V0O
Systematic Names
- 2H-1,4-Benzodiazepin-2-one, 7-bromo-1,3-dihydro-5-(2-pyridinyl)-
- 2H-1,4-Benzodiazepin-2-one, 7-bromo-1,3-dihydro-5-(2-pyridyl)-
- Bromazepam
Superlist Names
- Bromazepam
- DEA No. 2748
Registry Numbers
CAS Registry Number
- 1812-30-2
FDA UNII
- X015L14V0O
Other Registry Number
- 37355-30-9
System Generated Number
- 0001812302
Structure Descriptors
InChI
1S/C14H10BrN3O/c15-9-4-5-11-10(7-9)14(17-8-13(19)18-11)12-3-1-2-6-16-12/h1-7H,8H2,(H,18,19)InChIKey
VMIYHDSEFNYJSL-UHFFFAOYSA-NSmiles
C1(=NCC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 200mg/kg (200mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Journal of Drug Research. Vol. 16, Pg. 7, 1985. |
mouse | LD50 | oral | 879mg/kg (879mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE | Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 115, 1979. |
mouse | LD50 | rectal | > 5gm/kg (5000mg/kg) | Drugs in Japan Vol. -, Pg. 1048, 1990. | |
mouse | LD50 | subcutaneous | 6870mg/kg (6870mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE | Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 115, 1979. |
rabbit | LD50 | oral | 1690mg/kg (1690mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 158, 1972. | |
rat | LD50 | intraperitoneal | 1660mg/kg (1660mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE | Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 115, 1979. |
rat | LD50 | oral | 1950mg/kg (1950mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2413, 1973. |
rat | LD50 | rectal | > 5gm/kg (5000mg/kg) | Drugs in Japan Vol. -, Pg. 1048, 1990. | |
rat | LD50 | subcutaneous | 8800mg/kg (8800mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE | Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 115, 1979. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
log P (octanol-water) | 2.05 | (none) | EXP | |
Water Solubility | 175 | mg/L | 25 | EST |
Vapor Pressure | 1.90E-09 | mm Hg | 25 | EST |
Henry's Law Constant | 1.25E-13 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 5.79E-12 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.