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Substance Name: Ivacaftor mixture with lumacaftor
RN: 1815566-23-4
InChIKey: YQCGOSZYHRVOFW-UHFFFAOYSA-N

Note

  • DailyMed: ORKAMBI is a combination of lumacaftor and ivacaftor, a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, indicated for the treatment of cystic fibrosis (CF) in patients age 12 years and older who are homozygous for the F508del mutation in the CFTR gene.

Molecular Formula

  • C24-H28-N2-O3.C24-H18-F2-N2-O5

Molecular Weight

  • 844.9074
 
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Names and Synonyms

Results Name

  • Ivacaftor mixture with lumacaftor

Name of Substance

  • Lumacaftor, ivacaftor drug combination

Synonyms

  • Ivacaftor mixture with lumacaftor
  • Lumacaftor / Ivacaftor
  • Lumacaftor and ivacaftor
  • Lumacaftor and ivacaftor tablet
  • Orkambi
  • VX 700-VX 809 combination
  • VX 809-VX 770 combination

Registry Numbers

CAS Registry Number

  • 1815566-23-4

System Generated Number

  • 1815566234

Structure Descriptors

InChI

InChI=1S/C24H18F2N2O5.C24H28N2O3/c1-13-5-8-19(27-20(13)14-3-2-4-15(11-14)21(29)30)28-22(31)23(9-10-23)16-6-7-17-18(12-16)33-24(25,26)32-17;1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h2-8,11-12H,9-10H2,1H3,(H,29,30)(H,27,28,31);7-13,27H,1-6H3,(H,25,28)(H,26,29)

InChIKey

YQCGOSZYHRVOFW-UHFFFAOYSA-N

Smiles

Cc1ccc(NC(=O)C2(CC2)c3ccc4OC(F)(F)Oc4c3)nc1c5cccc(c5)C(=O)O.CC(C)(C)c6cc(c(NC(=O)C7=CNc8ccccc8C7=O)cc6O)C(C)(C)C