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Substance Name: Muscimol hydrobromide
RN: 18174-72-6
InChIKey: OPZOJWHOZRKYQX-UHFFFAOYSA-N

Note

  • Neurotoxic isoxazole isolated from Amanita muscaria and A. phalloides and also obtained by decarboxylation of IBOTENIC ACID. It is a potent agonist at GABA-A receptors and is used mainly as an experimental tool in animal and tissue studies.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C4-H6-N2-O2.Br-H

Molecular Weight

  • 195.015
 
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Names and Synonyms

Results Name

  • Muscimol hydrobromide

Synonyms

  • 5-(Aminomethyl)-3(2H)-isoxazolone hydrobromide
  • 5-(Aminomethyl)-3-isoxazolol monohydrobromide
  • Muscimol hydrobromide

Systematic Names

  • 3(2H)-Isoxazolone, 5-(aminomethyl)-, monohydrobromide
  • 3-Isoxazolol, 5-(aminomethyl)-, monohydrobromide (8CI)

Registry Numbers

CAS Registry Number

  • 18174-72-6

System Generated Number

  • 0018174726

Molecular Formulas

Molecular Formula

  • C4-H6-N2-O2.Br-H

Molecular Formula Fragments

  • Br-H
  • C4-H6-N2-O2
  • COMPONENT

Structure Descriptors

InChI

1S/C4H6N2O2.BrH/c5-2-3-1-4(7)6-8-3;/h1H,2,5H2,(H,6,7);1H

InChIKey

OPZOJWHOZRKYQX-UHFFFAOYSA-N

Smiles

o1[nH]c(cc1CN)=O.Br

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 13844ug/kg (13.844mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Neuropharmacology. Vol. 21, Pg. 803, 1982.