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Substance Name: Ethiazide [INN:BAN:JAN]
RN: 1824-58-4
UNII: EK9LSW731R
InChIKey: VXLCNTLWWUDBSO-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C9-H12-Cl-N3-O4-S2

Molecular Weight

  • 325.7958
 
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Names and Synonyms

Name of Substance

  • Ethiazide [INN:BAN:JAN]

Synonyms

  • 3-Ethylhydrochlorothiazide
  • Aethiazidum
  • Eclotizidum
  • EINECS 217-358-0
  • Ethiazide
  • Ethiazidum
  • Ethiazidum [INN-Latin]
  • Etiazida
  • Etiazida [INN-Spanish]
  • Etiazide
  • Etiazide [DCIT]
  • Neo-diuresal
  • Salta
  • UNII-EK9LSW731R

Systematic Names

  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-ethyl-3,4-dihydro-, 1,1-dioxide
  • 6-Chloro-3-ethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • Ethiazide

Registry Numbers

CAS Registry Number

  • 1824-58-4

FDA UNII

  • EK9LSW731R

System Generated Number

  • 0001824584

Structure Descriptors

InChI

1S/C9H12ClN3O4S2/c1-2-9-12-6-3-5(10)7(18(11,14)15)4-8(6)19(16,17)13-9/h3-4,9,12-13H,2H2,1H3,(H2,11,14,15)

InChIKey

VXLCNTLWWUDBSO-UHFFFAOYSA-N

Smiles

CCC1Nc2cc(c(cc2S(=O)(=O)N1)S(=O)(=O)N)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 10gm/kg (10000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 775, 1979.
mouse LD50 intravenous > 310mg/kg (310mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 775, 1979.
mouse LD50 oral > 2gm/kg (2000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 775, 1979.
mouse LD50 subcutaneous > 10gm/kg (10000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 775, 1979.
rat LD50 intraperitoneal > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. 110, 1982.
rat LD50 oral > 10gm/kg (10000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 775, 1979.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. 110, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 269-270 deg C   EXP
log P (octanol-water) 0.3 (none)   EXP
Water Solubility 427 mg/L 25 EST
Vapor Pressure 3.25E-10 mm Hg 25 EST
Henry's Law Constant 7.73E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.09E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.