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Substance Name: Cabazitaxel [USAN:INN]
RN: 183133-96-2
UNII: 51F690397J
InChIKey: BMQGVNUXMIRLCK-OAGWZNDDSA-N

Notes

  • An antineoplastic agent.
  • In multicenter phase II study for treatment of taxane-resistant metastatic breast cancer patients (2008).

    NCI: An orally bioavailable semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB).(NCI Drug Dictionary)

Molecular Formula

  • C45-H57-N-O14

Molecular Weight

  • 835.9383
 

Classification Code

  • Treatment of Metastatic Prostate Cancer

Names and Synonyms

Name of Substance

  • Cabazitaxel [USAN:INN]

Synonyms

  • Cabazitaxel
  • Cabazitaxel Injection
  • Cabazitaxelum
  • Jevtana
  • Jevtana Kit
  • RPR 116258A
  • Taxoid XRP6258
  • TXD 258
  • TXD258
  • UNII-51F690397J
  • XRP 6258
  • XRP-6258
  • XRP6258

Systematic Names

  • (((tertbutoxy)carbonyl)amino)-2-hydroxy-3-phenylpropanoate1-hydroxy-7beta,10beta-dimethoxy-9-oxo-5beta,20-epoxytax-11-ene-2alpha,4,13alpha-triyl 4-acetate 2-benzoate 13-((2R,3S)-3-
  • 1-hydroxy-7,10-dimethoxy-9-oxo-5,20-epoxytax-11-ene-2,4,13-triyl 4-acetate 2-benzoate 13-((2R,3S)-3-(((tertbutoxy)carbonyl)amino)-2-hydroxy-3-phenylpropanoate)

Registry Numbers

CAS Registry Number

  • 183133-96-2

FDA UNII

  • 51F690397J

Other Registry Number

  • 890654-44-1

System Generated Number

  • 0183133962

Structure Descriptors

InChI

1S/C45H57NO14/c1-24-28(57-39(51)33(48)32(26-17-13-11-14-18-26)46-40(52)60-41(3,4)5)22-45(53)37(58-38(50)27-19-15-12-16-20-27)35-43(8,36(49)34(55-10)31(24)42(45,6)7)29(54-9)21-30-44(35,23-56-30)59-25(2)47/h11-20,28-30,32-35,37,48,53H,21-23H2,1-10H3,(H,46,52)/t28-,29-,30+,32-,33+,34+,35-,37-,43+,44-,45+/m0/s1

InChIKey

BMQGVNUXMIRLCK-OAGWZNDDSA-N

Smiles

CO[C@H]1C[C@H]2OC[C@@]2(OC(=O)C)[C@H]3[C@H](OC(=O)c4ccccc4)[C@]5(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c6ccccc6)C(=C([C@@H](OC)C(=O)[C@]13C)C5(C)C)C