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Substance Name: Fluspirilene [USAN:INN:BAN]
RN: 1841-19-6
UNII: C5QA4GLR9M
InChIKey: QOYHHIBFXOOADH-UHFFFAOYSA-N

Note

  • A long-acting injectable antipsychotic agent used for chronic schizophrenia.

Molecular Formula

  • C29-H31-F2-N3-O

Molecular Weight

  • 475.58
 

Classification Codes

  • Antipsychotic
  • Antipsychotic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Dopamine Agents
  • Dopamine Antagonists
  • Drug / Therapeutic Agent
  • Human Data
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Tranquilizing Agents
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Names and Synonyms

Name of Substance

  • Fluspirilene
  • Fluspirilene [USAN:INN:BAN]

MeSH Heading

  • Fluspirilene

Synonyms

  • 1,3,8-Triazaspiro(4.5)decan-4-one, 8-(4,4-bis(4-fluorophenyl)butyl)-1-phenyl-
  • 1-Phenyl-4-oxo-8-(4,4-bis(4-fluorophenyl)butyl)-1,3,8-triazaspiro(4,5)decane
  • 5-26-04-00097 (Beilstein Handbook Reference)
  • 8-(4,4-Bis(p-fluorophenyl)butyl)-1-phenyl-1,3,8-triazaspiro-(4.5)decan-4-one
  • BRN 0633853
  • EINECS 217-418-6
  • Fluspirilene
  • Fluspirileno
  • Fluspirileno [INN-Spanish]
  • Fluspirilenum
  • Fluspirilenum [INN-Latin]
  • Imap
  • McN-JR-6218
  • R 6218
  • Redeptin
  • UNII-C5QA4GLR9M

Systematic Names

  • 1,3,8-Triazaspiro(4.5)decan-4-one, 8-(4,4-bis(4-fluorophenyl)butyl)-1-phenyl-
  • Fluspirilene

Registry Numbers

CAS Registry Number

  • 1841-19-6

FDA UNII

  • C5QA4GLR9M

System Generated Number

  • 0001841196

Structure Descriptors

InChI

1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35)

InChIKey

QOYHHIBFXOOADH-UHFFFAOYSA-N

Smiles

C12(C(NCN1c1ccccc1)=O)CCN(CCCC(c1ccc(cc1)F)c1ccc(cc1)F)CC2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intramuscular > 37mg/kg (37mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1689, 1970.
guinea pig LDLo intramuscular > 80mg/kg (80mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1689, 1970.
man TDLo intravenous 183ug/kg (0.183mg/kg) SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE British Medical Journal. Vol. 1, Pg. 523, 1979.
mouse LD50 intramuscular 106mg/kg (106mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1689, 1970.
rat LD50 intramuscular > 146mg/kg (146mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1689, 1970.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 5.86 (none)   EXP
Water Solubility 10 mg/L 25 EXP
Vapor Pressure 1.22E-13 mm Hg 25 EST
Henry's Law Constant 6.36E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.93E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.