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Substance Name: Gefitinib [USAN:INN:BAN]
RN: 184475-35-2
UNII: S65743JHBS
InChIKey: XGALLCVXEZPNRQ-UHFFFAOYSA-N

Note

  • NCI: An anilinoquinazoline with antineoplastic activity. Gefitinib inhibits the catalytic activity of numerous tyrosine kinases including the epidermal growth factor receptor (EGFR), which may result in inhibition of tyrosine kinase-dependent tumor growth. Specifically, this agent competes with the binding of ATP to the tyrosine kinase domain of EGFR, thereby inhibiting receptor autophosphorylation and resulting in inhibition of signal transduction. Gefitinib may also induce cell cycle arrest and inhibit angiogenesis. (NCI Thesaurus)

Molecular Formula

  • C22-H24-Cl-F-N4-O3

Molecular Weight

  • 446.908
 

Classification Codes

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Protein Kinase Inhibitors
  • Treatment of Advanced Non-Small Cell Lung Cancer, and a Range of Other Major Human Solid Tumor Types

Names and Synonyms

Name of Substance

  • Gefitinib
  • Gefitinib [USAN:INN:BAN]

Synonyms

  • 4-(3'-Chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline
  • CCRIS 9011
  • Gefitinib
  • Iressa
  • Irressat
  • UNII-S65743JHBS
  • ZD 1839
  • ZD1839

Systematic Name

  • 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-

Registry Numbers

CAS Registry Number

  • 184475-35-2

FDA UNII

  • S65743JHBS

System Generated Number

  • 0184475352

Structure Descriptors

InChI

1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)

InChIKey

XGALLCVXEZPNRQ-UHFFFAOYSA-N

Smiles

c12c(ncnc1cc(c(c2)OCCCN1CCOCC1)OC)Nc1cc(Cl)c(cc1)F