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Substance Name: Gefitinib hydrochloride
RN: 184475-55-6
InChIKey: QUINXWLATMJDQF-UHFFFAOYSA-N

Note

  • NCI: An anilinoquinazoline with antineoplastic activity. Gefitinib inhibits the catalytic activity of numerous tyrosine kinases including the epidermal growth factor receptor (EGFR), which may result in inhibition of tyrosine kinase-dependent tumor growth. Specifically, this agent competes with the binding of ATP to the tyrosine kinase domain of EGFR, thereby inhibiting receptor autophosphorylation and resulting in inhibition of signal transduction. Gefitinib may also induce cell cycle arrest and inhibit angiogenesis. (NCI Thesaurus)

Molecular Formula

  • C22-H24-Cl-F-N4-O3.Cl-H

Molecular Weight

  • 483.3685
 

Classification Code

  • Antineoplastic Agents
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Names and Synonyms

Name of Substance

  • Gefitinib hydrochloride

Synonyms

  • 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-, monohydrochloride
  • Gefitinib HCl

Registry Numbers

CAS Registry Number

  • 184475-55-6

System Generated Number

  • 0184475556

Structure Descriptors

InChI

1S/C22H24ClFN4O3.ClH/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15;/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27);1H

InChIKey

QUINXWLATMJDQF-UHFFFAOYSA-N

Smiles

Cl.COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN4CCOCC4