Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Nafoxidine hydrochloride [USAN:INN]
RN: 1847-63-8
UNII: SU8WBD61G1
InChIKey: HJOOGTROABIIIU-UHFFFAOYSA-N

Note

  • An estrogen antagonist that has been used in the treatment of breast cancer.

Molecular Formula

  • C29-H31-N-O2.Cl-H

Molecular Weight

  • 462.03
 

Classification Codes

  • Anti-Estrogen
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Nafoxidine hydrochloride [USAN:INN]

Synonyms

  • 1-(2-(p-(3,4-Dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy)ethyl)pyrrolidine hydrochloride
  • 1-(2-(p-(6-Methoxy-2-phenyl-3,4-dihydro-1-naphthyl)phenoxy)ethyl)pyrrolidine hydrochloride
  • CCRIS 3620
  • Nafoxidine HCl
  • Nafoxidine hydrochloride
  • NSC 70735
  • Pyrrolidine 1-(2-(4-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy)ethyl)-, hydrochloride
  • U 11100
  • U 11100A
  • U-11,100A
  • U-11100A
  • UNII-SU8WBD61G1

Systematic Names

  • Nafoxidine hydrochloride
  • Pyrrolidine 1-(2-(4-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy)ethyl)-, hydrochloride
  • Pyrrolidine, 1-(2-(p-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy)ethyl)-, hydrochloride

Registry Numbers

CAS Registry Number

  • 1847-63-8

FDA UNII

  • SU8WBD61G1

Related Registry Number

  • 1845-11-0 (Parent)

System Generated Number

  • 0001847638

Molecular Formulas

Molecular Formula

  • C29-H31-N-O2.Cl-H

Molecular Formula Fragments

  • C29-H31-N-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C29H31NO2.ClH/c1-31-26-14-16-28-24(21-26)11-15-27(22-7-3-2-4-8-22)29(28)23-9-12-25(13-10-23)32-20-19-30-17-5-6-18-30;/h2-4,7-10,12-14,16,21H,5-6,11,15,17-20H2,1H3;1H

InChIKey

HJOOGTROABIIIU-UHFFFAOYSA-N

Smiles

C=1(c2c(CCC1c1ccccc1)cc(OC)cc2)c1ccc(OCCN2CCCC2)cc1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 143mg/kg (143mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 112, Pg. 439, 1963.
rat LD50 oral 302mg/kg (302mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 112, Pg. 439, 1963.