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Substance Name: Chlorhexidine gluconate [USAN:USP:JAN]
RN: 18472-51-0
UNII: MOR84MUD8E
InChIKey: YZIYKJHYYHPJIB-UUPCJSQJSA-N

Molecular Formula

  • C22-H30-Cl2-N10.2C6-H12-O7

Molecular Weight

  • 897.7626
 

Classification Codes

  • Anti-Infective Agents
  • Anti-Infective Agents, Local
  • Antimicrobial
  • Antiviral (COVID-19)
  • Cosmetics
  • Dermatologic Agents
  • Drug / Therapeutic Agent
  • Mouthwashes
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Chlorhexidine digluconate
  • Chlorhexidine gluconate
  • Chlorhexidine gluconate [USAN:USP:JAN]

Synonyms

  • 1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide) di-D-gluconate
  • 1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide) gluconate
  • 1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide)digluconate
  • 1,6-Bis(5-(p-chlorophenyl)biguandino)hexane digluconate
  • 2,4,11,13-Tetraazatetradecanediimidamide, N,N'-bis(4-chlorophenyl)-3,12-diimino-, di-D-gluconate
  • Abacil
  • Arlacide G
  • Bacticlens
  • Bactoshield CHG 2%
  • Biguanide, 1,1'-hexamethylenebis(5-(p-chlorophenyl)-, digluconate
  • Bioscrub
  • Brian Care
  • Caswell No. 481G
  • CHG Scrub
  • ChloraPrep
  • Chlorhexidin glukonatu
  • Chlorhexidin glukonatu [Czech]
  • Chlorhexidine D-digluconate
  • Chlorhexidine di-D-gluconate
  • Chlorhexidine digluconate
  • Chlorhexidine gluconate
  • Chx plus concentrate premium chlorhexidine teat dip concentrate
  • Cida-Stat
  • Corsodyl
  • Disteryl
  • DRG-0091
  • Dyna-hex
  • E-Z Scrub
  • EC 242-354-0
  • EINECS 242-354-0
  • EPA Pesticide Chemical Code 045504
  • Exidine
  • Fight bac
  • Hibiclens
  • Hibidil
  • Hibiscrub
  • Hibistat
  • Hibitane
  • Hibitane 5
  • Kleersight
  • Microderm
  • NSC 753971
  • Orahexal
  • Peridex
  • Peridex (antiseptic)
  • Periochip
  • Periogard
  • Pharmaseal Scrub Care
  • Plac out
  • Plurexid
  • Prevacare
  • Prevacare R
  • Septeal
  • Steri-Stat
  • UNII-MOR84MUD8E
  • Unisept

Systematic Names

  • 2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, di-D-gluconate
  • D-Gluconic acid, compd. with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecane diimidamide (2:1)
  • D-Gluconic acid, compd. with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)
  • D-Gluconic acid, compd. with N1,N14-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)
  • D-Gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1)
  • Gluconic acid, compd. with 1,1'-hexamethylene bis(5-(p-chlorophenyl)biguanide) (2:1), D-

Superlist Name

  • 1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide), digluconate

Mixture Names

  • Hibistat
  • PwrioChip

Registry Numbers

CAS Registry Number

  • 18472-51-0

FDA UNII

  • MOR84MUD8E

Other Registry Numbers

  • 105791-72-8
  • 12068-31-4
  • 124973-71-3
  • 14007-07-9
  • 150621-85-5
  • 151498-43-0
  • 21293-24-3
  • 227749-99-7
  • 230296-52-3
  • 23289-58-9
  • 40330-16-3
  • 452971-25-4
  • 51365-13-0
  • 52196-45-9
  • 52387-19-6
  • 60042-57-1
  • 60404-86-6
  • 82432-16-4
  • 906339-38-6

System Generated Number

  • 0018472510

Molecular Formulas

Molecular Formula

  • C22-H30-Cl2-N10.2C6-H12-O7

Molecular Formula Fragments

  • C22-H30-Cl2-N10
  • C6-H12-O7
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C22H30Cl2N10.2C6H12O7/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*7-1-2(8)3(9)4(10)5(11)6(12)13/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*2-5,7-11H,1H2,(H,12,13)/t;2*2-,3-,4+,5-/m.11/s1

InChIKey

YZIYKJHYYHPJIB-UUPCJSQJSA-N

Smiles

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(=O)O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(=O)O.Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 12900ug/kg (12.9mg/kg)   Drugs in Japan Vol. 6, Pg. 255, 1982.
mouse LD50 oral 1260mg/kg (1260mg/kg)   Drugs in Japan Vol. 6, Pg. 255, 1982.
mouse LD50 subcutaneous 1140mg/kg (1140mg/kg)   Drugs in Japan Vol. 6, Pg. 255, 1982.
rat LD50 intravenous 24200ug/kg (24.2mg/kg)   Drugs in Japan Vol. 6, Pg. 255, 1982.
rat LD50 oral 2gm/kg (2000mg/kg)   Drugs in Japan Vol. 6, Pg. 255, 1982.
rat LD50 subcutaneous 3320mg/kg (3320mg/kg)   Drugs in Japan Vol. 6, Pg. 255, 1982.