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Substance Name: Vinrosidine sulfate [USAN]
RN: 18556-44-0
UNII: 4944BQ2GBF
InChIKey: KDQAABAKXDWYSZ-SDCRJXSCSA-N

Classification Codes

  • Antineoplastic
  • Drug / Therapeutic Agent

Molecular Formula

  • C46-H58-N4-O9.x-H2-O4-S

Molecular Weight

  • 909.061
 
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Names and Synonyms

Name of Substance

  • Vinrosidine sulfate [USAN]

Synonyms

  • (4'-alpha)Vincaleukoblastine sulfate
  • 36781
  • Leurosidine sulfate
  • UNII-4944BQ2GBF
  • Vincaleucoblastine, 4'-deoxy-3'-hydroxy-, sulfate (salt)
  • Vinrosidine sulfate

Systematic Names

  • Leurosidine, sulfate (salt)
  • Vincaleucoblastine, 4'-deoxy-3'-hydroxy-, sulfate (salt)
  • Vincaleukoblastine, (4'-alpha)-, sulfate (9CI)

Registry Numbers

CAS Registry Number

  • 18556-44-0

FDA UNII

  • 4944BQ2GBF

System Generated Number

  • 0018556440

Molecular Formulas

Molecular Formula

  • C46-H58-N4-O9.x-H2-O4-S

Molecular Formula Fragments

  • C46-H58-N4-O9
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42+,43+,44+,45-,46-;/m0./s1

InChIKey

KDQAABAKXDWYSZ-SDCRJXSCSA-N

Smiles

CC[C@]1(C[C@H]2C[C@@](c3c(c4ccccc4[nH]3)CC[N@](C2)C1)(c5cc6c(cc5OC)N([C@@H]7[C@]68CCN9[C@H]8[C@@](C=CC9)([C@H]([C@@]7(C(=O)OC)O)OC(=O)C)CC)C)C(=O)OC)O.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo intraperitoneal 100mg/kg (100mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) "Catharanthus Alkaloids," Taylor, W.I., and N.R. Farnsworth, eds., New York, Marcel Dekker, 1975Vol. -, Pg. 72, 1975.