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Substance Name: Tretoquinol l-form hydrochloride
RN: 18559-59-6
UNII: 298SP836N4
InChIKey: UHSXRTHJCJGEKG-UQKRIMTDSA-N

Note

  • An Adrenergic beta-agonist used as a bronchodilator agent in asthma therapy.

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C19-H23-N-O5.Cl-H

Molecular Weight

  • 381.8536
 
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Names and Synonyms

Name of Substance

  • Tretoquinol
  • Tretoquinol l-form hydrochloride

MeSH Heading

  • Tretoquinol

Synonyms

  • 1-(3,4,5-Trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, L-
  • AQL 208
  • CCRIS 1913
  • EINECS 242-423-5
  • Inolin
  • l-1-(3,4,5-Trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
  • L-1-(3,4,5-Trimethylbenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
  • l-Trimetoquinol
  • NSC 288748
  • Trikvinol (triquinol) hydrochloride
  • Trimethoquinol
  • Trimethoquinol (VAN)
  • Trimetoquinol
  • Trimetoquinol (VAN)
  • Trimetoquinol hydrochloride
  • Trimetoquinol-hydrochloride
  • Triquinol
  • UNII-298SP836N4

Systematic Names

  • (S)-1,2,3,4-Tetrahydro-6,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride
  • 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-((3,4,5-trimethoxyphenyl)methyl)-, hydrochloride, (S)-
  • 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-(3,4,5-trimethoxybenzyl)-, hydrochloride, (-)-
  • Triquinol

Registry Numbers

CAS Registry Number

  • 18559-59-6

FDA UNII

  • 298SP836N4

System Generated Number

  • 0018559596

Molecular Formulas

Molecular Formula

  • C19-H23-N-O5.Cl-H

Molecular Formula Fragments

  • C19-H23-N-O5
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C19H23NO5.ClH/c1-23-17-7-11(8-18(24-2)19(17)25-3)6-14-13-10-16(22)15(21)9-12(13)4-5-20-14;/h7-10,14,20-22H,4-6H2,1-3H3;1H/t14-;/m0./s1

InChIKey

UHSXRTHJCJGEKG-UQKRIMTDSA-N

Smiles

COc1cc(cc(c1OC)OC)C[C@H]2c3cc(c(cc3CCN2)O)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 160mg/kg (160mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
European Journal of Pharmacology. Vol. 5, Pg. 303, 1968.
guinea pig LD50 intraperitoneal 505mg/kg (505mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
European Journal of Pharmacology. Vol. 5, Pg. 303, 1968.
guinea pig LD50 oral > 2gm/kg (2000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64, Pg. 268, 1968.
guinea pig LD50 subcutaneous 1470mg/kg (1470mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
European Journal of Pharmacology. Vol. 5, Pg. 303, 1968.
mouse LD50 intraperitoneal 370mg/kg (370mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
European Journal of Pharmacology. Vol. 5, Pg. 303, 1968.
mouse LD50 intravenous 120mg/kg (120mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64, Pg. 268, 1968.
mouse LD50 oral 2250mg/kg (2250mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64, Pg. 268, 1968.
mouse LD50 subcutaneous 2gm/kg (2000mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
European Journal of Pharmacology. Vol. 5, Pg. 303, 1968.
rat LD50 intraperitoneal 298mg/kg (298mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
European Journal of Pharmacology. Vol. 5, Pg. 303, 1968.
rat LD50 intravenous 164mg/kg (164mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
European Journal of Pharmacology. Vol. 5, Pg. 303, 1968.
rat LD50 oral 2gm/kg (2000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 2331, 1982.
rat LD50 subcutaneous 1100mg/kg (1100mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
European Journal of Pharmacology. Vol. 5, Pg. 303, 1968.