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Substance Name: Tretoquinol dl-form hydrochloride
RN: 18559-63-2
UNII: 100GVI988J
InChIKey: UHSXRTHJCJGEKG-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C19-H23-N-O5.Cl-H

Molecular Weight

  • 381.8536
 
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Names and Synonyms

Name of Substance

  • Tretoquinol dl-form hydrochloride

Synonyms

  • (+-)-1,2,3,4-Tetrahydro-1-(3,4,5-trimethoxybenzyl)-6,7-isoquinolinediol hydrochloride
  • (+-)-Trimethoquinol
  • (+-)-Trimetoquinol hydrochloride
  • 1,2,3,4-Tetrahydro-1-(3,4,5-trimethoxyphenyl)-6,7-isoquinolinediol hydrochloride
  • AQ 110
  • dl-1-(3,4,5-Trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
  • Tretoquinol dl-form HCl
  • UNII-100GVI988J

Systematic Names

  • 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-(3,4,5-trimethoxybenzyl)-, hydrochloride, (+-)-
  • 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-(3,4,5-trimethoxyphenyl)-, hydrochloride

Registry Numbers

CAS Registry Number

  • 18559-63-2

FDA UNII

  • 100GVI988J

Other Registry Number

  • 14187-92-9

System Generated Number

  • 0018559632

Molecular Formulas

Molecular Formula

  • C19-H23-N-O5.Cl-H

Molecular Formula Fragments

  • C19-H23-N-O5
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C19H23NO5.ClH/c1-23-17-7-11(8-18(24-2)19(17)25-3)6-14-13-10-16(22)15(21)9-12(13)4-5-20-14;/h7-10,14,20-22H,4-6H2,1-3H3;1H

InChIKey

UHSXRTHJCJGEKG-UHFFFAOYSA-N

Smiles

COc1cc(cc(c1OC)OC)CC2c3cc(c(cc3CC[NH2+]2)O)O.[Cl-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intraperitoneal 660mg/kg (660mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
European Journal of Pharmacology. Vol. 5, Pg. 303, 1968.
guinea pig LD50 oral > 2gm/kg (2000mg/kg)   European Journal of Pharmacology. Vol. 5, Pg. 303, 1968.
mouse LD50 intraperitoneal 340mg/kg (340mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
European Journal of Pharmacology. Vol. 5, Pg. 303, 1968.
mouse LD50 intravenous 130mg/kg (130mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
European Journal of Pharmacology. Vol. 5, Pg. 303, 1968.
mouse LD50 oral > 2gm/kg (2000mg/kg)   European Journal of Pharmacology. Vol. 5, Pg. 303, 1968.
mouse LD50 subcutaneous 480mg/kg (480mg/kg)   Pharmaceutical Chemistry Journal Vol. 18, Pg. 262, 1984.
rat LD50 intraperitoneal 311mg/kg (311mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
European Journal of Pharmacology. Vol. 5, Pg. 303, 1968.
rat LD50 intravenous 174mg/kg (174mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
European Journal of Pharmacology. Vol. 5, Pg. 303, 1968.
rat LD50 oral > 2gm/kg (2000mg/kg)   European Journal of Pharmacology. Vol. 5, Pg. 303, 1968.
rat LD50 subcutaneous > 2gm/kg (2000mg/kg)   European Journal of Pharmacology. Vol. 5, Pg. 303, 1968.