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Substance Name: Iodamide Meglumine [USAN]
RN: 18656-21-8
UNII: 6X283535A3
InChIKey: UYIPQECISAQMIU-WZTVWXICSA-N

Classification Codes

  • Diagnostic Aid (Radiopaque Medium)
  • Drug / Therapeutic Agent

Molecular Formula

  • C12-H11-I3-N2-O4.C7-H17-N-O5

Molecular Weight

  • 823.1422
 
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Names and Synonyms

Name of Substance

  • Iodamide Meglumine [USAN]
  • Iodamide N-methyl-D-glucamine salt
  • Meglumine iodamide

Synonyms

  • alpha,5-Diacetamido-2,4,6-triiodo-m-toluic acid compound with 1-deoxy-1-(methylamino)-D-glucitol (1:1)
  • Benzoic acid, 3-(acetylamino)-5-((acetylamino)methyl)-2,4,6-triiodo-, compound with 1-deoxy-1-(methylamino)-D-glucitol (1:1)
  • Conraxin H
  • EINECS 242-480-6
  • Iodamide 300
  • Iodamide meglumine
  • Iodamide methylglucamine
  • Isteropac E.R.
  • Jodamid methylglucaminsalz
  • Jodamid methylglucaminsalz [German]
  • Meglumine iodamide
  • Meglumine iodamide injection
  • Meglumine Sodium Iodamide Injection [JAN]
  • Opacist E.R.
  • Renovue
  • Renovue-65
  • Renovue-DIP
  • UNII-6X283535A3

Systematic Names

  • 1-Deoxy-1-(methylamino)-D-glucitol alpha,5-diacetamido-2,4,6-triiodo-m-toluate
  • Benzoic acid, 3-(acetylamino)-5-((acetylamino)methyl)-2,4,6-triiodo-, compound with 1-deoxy-1-(methylamino)-D-glucitol (1:1)
  • Glucitol, 1-deoxy-1-(methylamino)-, alpha,5-diacetamido-2,4,6-triiodo-m-toluate (salt), D-

Registry Numbers

CAS Registry Number

  • 18656-21-8

FDA UNII

  • 6X283535A3

Other Registry Numbers

  • 16240-58-7
  • 523-89-7
  • 63087-14-9

System Generated Number

  • 0018656218

Molecular Formulas

Molecular Formula

  • C12-H11-I3-N2-O4.C7-H17-N-O5

Molecular Formula Fragments

  • C12-H11-I3-N2-O4
  • C7-H17-N-O5
  • COMPONENT

Structure Descriptors

InChI

1S/C12H11I3N2O4.C7H17NO5/c1-4(18)16-3-6-8(13)7(12(20)21)10(15)11(9(6)14)17-5(2)19;1-8-2-4(10)6(12)7(13)5(11)3-9/h3H2,1-2H3,(H,16,18)(H,17,19)(H,20,21);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1

InChIKey

UYIPQECISAQMIU-WZTVWXICSA-N

Smiles

CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CC(=O)NCc1c(I)c(NC(=O)C)c(I)c(C(=O)O)c1I

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD intravenous > 15mL/kg (15mL/kg)   Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 222, 1965.
guinea pig LD50 intraperitoneal 15gm/kg (15000mg/kg) CARDIAC: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 222, 1965.
mammal (species unspecified) LD50 oral > 20gm/kg (20000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 222, 1965.
mouse LD50 intracrebral 200mg/kg (200mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 222, 1965.
mouse LD50 intravenous 9gm/kg (9000mg/kg) CARDIAC: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 222, 1965.
rabbit LD50 intravenous 13200mg/kg (13200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 222, 1965.
rat LD50 intraperitoneal 17900mg/kg (17900mg/kg) CARDIAC: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 222, 1965.
rat LD50 intravenous 11400mg/kg (11400mg/kg) CARDIAC: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 222, 1965.