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Substance Name: Chlormethiazole edisylate
RN: 1867-58-9
UNII: 22NJI0W1D2
InChIKey: WFVBVWRCFZCWJU-UHFFFAOYSA-N

Note

  • Used in therapy of delirium tremens.

Molecular Formula

  • C6-H8-Cl-N-S.1/2C2-H6-O6-S2

Molecular Weight

  • 513.5058
 

Classification Codes

  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Human Data
  • Hypnotics and Sedatives
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Names and Synonyms

Name of Substance

  • Chlormethiazole edisylate
  • Clomethiazole edisylate

Synonyms

  • 5-(2-Chloroethyl)-4-methylthiazole ethanedisulfonate (2:1)
  • Bis(4-methyl-5-(2-chlorethyl)thiazol)ethandisulfonat
  • Chlormethiazole edisylate
  • Chlormethiazole ethandisulfonate
  • Chlormethiazole ethanedisulfonate
  • Clomethiazol edisilat
  • Clomethiazole edisylate
  • Clomethiazole ethanedisulfonate
  • Distraneurin
  • EINECS 217-483-0
  • Heminevrin
  • Hemithiamine
  • SCTZ
  • Thiazole, 5-(2-chloroethyl)-4-methyl-, ethanedisulfonate (2:1)
  • UNII-22NJI0W1D2

Systematic Names

  • 1,2-Ethanedisulfonic acid, compd. with 5-(2-chloroethyl)-4-methylthiazole (1:2)
  • Ethane-1,2-disulphonic acid, compound with 5-(2-chloroethyl)-4-methylthiazole (1:2)

Registry Numbers

CAS Registry Number

  • 1867-58-9

FDA UNII

  • 22NJI0W1D2

System Generated Number

  • 0001867589

Molecular Formulas

Molecular Formula

  • C6-H8-Cl-N-S.1/2C2-H6-O6-S2

Molecular Formula Fragments

  • C2-H6-O6-S2
  • C6-H8-Cl-N-S
  • COMPONENT

Structure Descriptors

InChI

1S/2C6H8ClNS.C2H6O6S2/c2*1-5-6(2-3-7)9-4-8-5;3-9(4,5)1-2-10(6,7)8/h2*4H,2-3H2,1H3;1-2H2,(H,3,4,5)(H,6,7,8)

InChIKey

WFVBVWRCFZCWJU-UHFFFAOYSA-N

Smiles

Cc1ncsc1CCCl.Cc2ncsc2CCCl.OS(=O)(=O)CCS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 380mg/kg (380mg/kg) BEHAVIORAL: SLEEP Farmakologiya i Toksikologiya Vol. 25, Pg. 657, 1962.
mouse LD50 intravenous 150mg/kg (150mg/kg)   Acta Pharmaceutica Suecica. Vol. 4, Pg. 269, 1967.
mouse LD50 oral 835mg/kg (835mg/kg)   Acta Pharmaceutica Suecica. Vol. 4, Pg. 269, 1967.
mouse LD50 subcutaneous 620mg/kg (620mg/kg)   Acta Pharmaceutica Suecica. Vol. 4, Pg. 269, 1967.
women TDLo intravenous 1560mg/kg/4D- (1560mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Intensive Care Medicine. Vol. 10, Pg. 315, 1984.