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Substance Name: Epirizole [USAN:INN:JAN]
RN: 18694-40-1
UNII: 3B46O2FH8I
InChIKey: RHAXSHUQNIEUEY-UHFFFAOYSA-N

Note

  • 4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine. A pyrimidinyl pyrazole with antipyretic, analgesic, and anti-inflammatory activity.

Molecular Formula

  • C11-H14-N4-O2

Molecular Weight

  • 234.2576
 

Classification Codes

  • Analgesic
  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Peripheral Nervous System Agents
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Epirizole
  • Epirizole [USAN:INN:JAN]

MeSH Heading

  • Epirizole

Synonyms

  • 1-(4-Methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole
  • 2-(3-Methoxy-5-methylpyrazol-2-yl)-4-methoxy-6-methylpyrimidine
  • 2-(3-Methyl-5-methoxy-1-pyrazolyl)-4-methoxy-6-methylpyrimidine
  • 4-Methoxy-2-(5-methoxy-3-methyl-1H-pyrazol-1-yl)-6-methylpyrimidine
  • 4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidin
  • 4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidin [German]
  • 4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine
  • 5-25-18-00012 (Beilstein Handbook Reference)
  • BRN 0751084
  • DA-398
  • EINECS 242-507-1
  • Epirizol
  • Epirizol [INN-Spanish]
  • Epirizole
  • Epirizolum
  • Epirizolum [INN-Latin]
  • Mebron
  • Mepirizol
  • Mepirizol [German]
  • Mepirizole
  • UNII-3B46O2FH8I

Systematic Names

  • Epirizole
  • Pyrimidine, 4-methoxy-2-(5-methoxy-3-methyl-1H-pyrazol-1-yl)-6-methyl-

Registry Numbers

CAS Registry Number

  • 18694-40-1

FDA UNII

  • 3B46O2FH8I

System Generated Number

  • 0018694401

Structure Descriptors

InChI

1S/C11H14N4O2/c1-7-5-9(16-3)13-11(12-7)15-10(17-4)6-8(2)14-15/h5-6H,1-4H3

InChIKey

RHAXSHUQNIEUEY-UHFFFAOYSA-N

Smiles

Cc1cc(nc(n1)n2c(cc(n2)C)OC)OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 540mg/kg (540mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 1011, 1978.
mouse LD50 intravenous 550mg/kg (550mg/kg)   Japan Medical Gazette. Vol. 7(9), Pg. 5, 1970.
mouse LD50 oral 740mg/kg (740mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 1011, 1978.
mouse LD50 subcutaneous 550mg/kg (550mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 494, 1977.
rat LD50 intraperitoneal 214mg/kg (214mg/kg)   Japan Medical Gazette. Vol. 7(9), Pg. 5, 1970.
rat LD50 intravenous 214mg/kg (214mg/kg)   "Modern Pharmaceuticals of Japan, V," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1975Vol. -, Pg. 87, 1975.
rat LD50 oral 445mg/kg (445mg/kg)   Japan Medical Gazette. Vol. 7(9), Pg. 5, 1970.
rat LD50 subcutaneous 208mg/kg (208mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 494, 1977.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 90-92 deg C   EXP
log P (octanol-water) 1.26 (none)   EXP
Water Solubility 2420 mg/L 25 EST
Vapor Pressure 6.09E-06 mm Hg 25 EST
Henry's Law Constant 2.83E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.02E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.