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Substance Name: Actarit [INN:JAN]
RN: 18699-02-0
UNII: HW5B6351RZ
InChIKey: MROJXXOCABQVEF-UHFFFAOYSA-N

Classification Codes

  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C10-H11-N-O3

Molecular Weight

  • 193.2009
 
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Names and Synonyms

Name of Substance

  • 4-(Acetylamino)benzeneacetic acid
  • Actarit
  • Actarit [INN:JAN]

Synonyms

  • (p-Acetamidophenyl)acetic acid
  • 2-14-00-00281 (Beilstein Handbook Reference)
  • 4-(Acetylamino)benzeneacetic acid
  • 4-Acetamidophenylacetic acid
  • 4-N-Acetylaminophenylacetic acid
  • Actarit
  • Actaritum
  • Actaritum [INN-Latin]
  • BRN 1640927
  • CCRIS 3777
  • EINECS 242-511-3
  • MS 932
  • NSC 170317
  • UNII-HW5B6351RZ

Systematic Names

  • (p-Acetamidophenyl)acetic acid
  • 4-Acetamidophenylacetic acid
  • 4-Acetylaminophenylacetic acid
  • Acetic acid, (p-acetamidophenyl)- (6CI,8CI)
  • Benzeneacetic acid, 4-(acetylamino)-

Registry Numbers

CAS Registry Number

  • 18699-02-0

FDA UNII

  • HW5B6351RZ

System Generated Number

  • 0018699020

Structure Descriptors

InChI

1S/C10H11NO3/c1-7(12)11-9-4-2-8(3-5-9)6-10(13)14/h2-5H,6H2,1H3,(H,11,12)(H,13,14)

InChIKey

MROJXXOCABQVEF-UHFFFAOYSA-N

Smiles

CC(=O)Nc1ccc(cc1)CC(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 6050mg/kg (6050mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 117, 1990.
guinea pig LD50 oral 4400mg/kg (4400mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: ATAXIA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 117, 1990.
mouse LD50 intraperitoneal 1060mg/kg (1060mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 117, 1990.
mouse LD50 oral 14700mg/kg (14700mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 117, 1990.
mouse LD50 subcutaneous 5480mg/kg (5480mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 117, 1990.
rat LD50 intraperitoneal 1950mg/kg (1950mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 117, 1990.
rat LD50 oral 14800mg/kg (14800mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 117, 1990.
rat LD50 subcutaneous 5480mg/kg (5480mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Oyo Yakuri. Pharmacometrics. Vol. 40, Pg. 117, 1990.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 173 deg C   EXP
log P (octanol-water) 0.540 (none)   EST
Atmospheric OH Rate Constant 1.41E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.